The ALK1 (ALK1 cline) antibody labels normal human ALK protein and the NPM-ALK chimeric protein, and is a useful tool for the identification of the su...
IHC
Amyloid P component reacts with all types of amyloid deposits, however, it is also present in normal elastic tissue and basement membranes. The appl...
B-cell lymphoma 2 (BCL2) was the first of the translocation-associated proteins to be identified in lymphoma. Most cases of follicular lymphoma have ...
Beta-catenin is an important regulator of cell–cell adhesion and embryogenesis. Mutations of beta-catenin could lead to some human cancers. Normal cel...
Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction. Two closely related variants of human caldesmon...
Anti-Cytokeratin (CAM 5.2) has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 Kd. Cytoker...
CD163 antigen is restricted in its expression to the monocytic/macrophage lineage. It is present on all circulating monocytes and most tissue macropha...
CD31 is a 130kDa transmembrane glycoprotein that is shared by vascular lining cells, megakaryocytes and platelets. This marker is highly restricted to...
CD99 (MIC2 gene product, E2) antigen is strongly expressed by Ewing sarcoma cells, primitive peripheral neuroectodermal tumors, and lymphoblastic leuk...
Among cyclin/CDK proteins, CDK4 and cyclin D1 are the most frequently activated by somatic genetic alterations in multiple tumor types. CDK4 antibody...
A wide variety of abnormalities can be identified, providing both diagnostic and prognostic information. Acute leukemias, lymphomas and chronic mye...
Cytogenetics
Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin, respectively, thus the combination of these two antibodie...
CK903 (34betaE12) is a high molecular weight cytokeratin present in all squamous epithelium and their carcinomas. This antibody recognizes cytokeratin...
Cytokeratin 20 (CK20) positivity is seen in the majority of adenocarcinomas of the colon, mucinous ovarian carcinomas, transitional cell, and Merkel c...
Probes: DDIT3 (CHOP) (12q13)Disease(s): Myxoid-round cell liposarcoma (M/RCLS)
FISH
DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with Kit mutation...
This probe set labels all latent EBV-infected cells, including EBV-positive lymphoblastoid cell lines and EBV infected B-cell immunoblasts in infec...
ISH
ERG oncoprotein expression has been shown to be a highly specific marker for prostate cancer. Given the lack of ERG expression in a wide variety of no...
Probes: EWSR1 (22q12) Disease(s): Ewing sarcoma, primitive neuroectodermal tumor (PNET)
Factor VIII-related antigen is a component of Factor VIII complex. Factor VIII-related antigen is one of the available immunohistochemical markers of ...
Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has ...
Friend leukemia integration (FLI1) is a nuclear transcription factor and has been reported as the first nuclear marker of endothelial differentiation....
Glial Fibrillary Acidic Protein (GFAP) is the major protein found in astrocytes and its expression is evidence of astroglial origin and differentiatio...
Glucose transporter 1 (GLUT1) facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT-1 is expressed in many human ...
Bi-directional sequencing of exons 8 and 9 of the GNAS gene to detect mutation hot spots in codons R201 and Q227.
Molecular
The Hereditary Cancer Susceptibility for Pediatrics panel is a sequencing based assay that can detect mutations in the entire coding region of the following genes listed. ALK, APC, BRCA1, BRCA2, CDH1, KRAS, MSH2, MSH6, NF1, NF2, NRAS, PALB2, PMS2, PTCH1, RB1, RET, RUNX1, SDHA, SDHB, TP53, and VHL. Note: Parent and physician or genetic counselor signatures on the NeoGenomics Consent for Hereditary Cancer Genetic Testing form...
Human Herpes Virus (HHV) 8 is the likely etiological agent of Kaposi’s sarcoma (KS), and is present in all cases. HHV 8 encodes a latent nuclear ant...
Lack of nuclear expression of INI1 is characteristic of malignant rhabdoid tumors and epithelioid sarcomas.
Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cel...
Bi-directional sequencing of exon 4 of the KRAS gene corresponding to amino acids R97 through Q150. Codon 117 and 146 mutations are det...
Bi-directional sequencing of exons 2 and 3 of the KRAS gene. High-sensitivity sequencing is used for enhanced detection of mutations in codons 12, ...
Probes: MDM2 (12q15) | Centromere 12 Disease(s): Liposarcoma
Muscle Specific Actin (MSA) antibody recognizes the alpha and gamma isotypes of skeletal, cardiac, and smooth muscle cells. It is non-reactive with ot...
MUC4 is useful in the identification of low-grade fibromyxoid sarcoma (LGFMS) and sclerosing epithelioid fibrosarcoma.
Nuclear expression of myogenic differentiation 1 (MyoD1) is restricted to skeletal muscle tissue and has been demonstrated to be a sensitive marker of...
Expression of myogenin is restricted to cells of skeletal muscle origin. It is a useful marker for tumors of the muscle lineage, being strongly expres...
Myoglobin is found in skeletal and cardiac muscle but not in smooth muscle. Because myoglobin appears relatively late in the maturational sequence of ...
The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverag...
The NeoLAB™ Solid Tumor Monitor is a blood test that uses cell-free circulating tumor DNA (ctDNA) or RNA in combination with next-generation ...
This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. ABL1, ABL2, ACVR1B, AKT1, AKT2, ...
This test is performed by the sequencing of select exons of the genes listed. AKT1, BRAF, CTNNB1, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, KIT, PDGFRA, S...
The NeoTYPE Liposarcoma Fusion Profile combines next-generation sequencing to detect translocations in the genes EWSR1, FUS, HMGA2, and PLAG1 with ...
This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. AKT1, BRAF, EGFR, FGFR1, FGFR2, ...
The NeoTYPE Precision Profile for Solid Tumors utilizes next-generation sequencing to detect mutations in the following 48 genes: ABL1, AKT1, ALK, ...
This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. AKT1, BRAF, FGFR1, FGFR2, FGFR3,...
Neurofilaments (NFs) are the intermediate filaments of neurons and their processes. NFs are expressed in tumors of neural origin or tumors displaying ...
The NGS Comprehensive Sarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect 134 different translocations relevant ...
The NGS Ewing Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations relevant in Ewing's sarcoma ...
The NGS Non-Ewing Sarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations unrelated to Ewing&#...
The NGS Pediatric Sarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations related to pediatric...
The NGS Rhabdomyosarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations related to rhabdomyos...
Homeobox protein NKX2.2 plays a critical role in neuroendocrine/glial differentiation. The NKX2.2 gene was recently identified as a target of E...
In normal tissue, most neurons and their axonal and dendritic processes stain strongly positive for Neuron Specific Enolase (NSE), with the exception ...
p21 is a cyclin dependent protein kinase inhibitor and is a member of a family of proteins that functions to slow down cell division. p21 is found in ...
The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results ...
Bi-directional sequencing of exons 12 and 18 of the PDGFRA (platelet-derived growth factor alpha) gene. These ...
Phosphohistone H3 (PHH3) is a marker of cells in the late G2-M phase of the cell cycle. It is not expressed in apoptotic cells which may be confused w...
Normally human Placental Alkaline Phosphatase (PLAP) is produced by syncytiotrophoblasts after the twelfth week of pregnancy. PLAP is expressed by bot...
Bi-directional sequencing of all exons (1-9) of the PTEN gene. For solid tumors, enrichment is performed befor...
S100 belongs to the family of calcium binding proteins. Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign melanocytic ...
Smooth Muscle Myosin, Heavy Chain (SMMS-1) is an antibody to smooth muscle myosin, heavy chain that reacts with human visceral and vascular smooth mus...
SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is also a useful marker in detecting both the...
Probes: SS18 (SYT) (18q11.2)Disease(s): Synovial sarcoma
STAT6 is a highly sensitive and specific immunohistochemical marker for solitary fibrous tumor (SFT) and can be helpful to distinguish this tumor type...
Antibody to synaptophysin reacts with neuroendocrine neoplasms of neural as well as epithelial types. In combination with chromogranin A and NSE antib...
Overexpression of TFE3 is a sensitive and specific marker of Xp11 translocation in renal cell carcinomas. TFE3 is also expressed in alveolar soft par...
Expression of the transducing-like receptor (TLE) genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that...
Bi-directional sequencing of TP53 exons 4-9.
Tumor Mutation Burden (TMB) testing at NeoGenomics measures the number of non-synonymous DNA coding sequence changes per megabase of sequenced DNA....
The Universal Fusion/Expression Profile is a targeted RNA sequencing panel that utilizes next-generation sequencing (NGS) to detect all relevant fusion transcripts in 1,385 genes associated with hematologic or solid tumor cancers. It is especially useful for testing patients with rare diseases. Learn more about the Universal Fusion/Expression Profile...
Vimentin is the major intermediate filament in a variety of mesenchymal cells, including endothelial cells, all fibroblastic cells, macrophages, Serto...