Displaying 1 - 293 of 293 tests
Chromosome Analysis A wide variety of abnormalities can be identified, providing both diagnostic and prognostic information. Acute leukemias, lymphomas and chronic myeloid and lymphoid disorders are examined…
Cytogenetics
NeoARRAY™ SNP/Cytogenetic Profile The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage available, this test employs an enhanced SNP…
Cytogenetics
1p/19q Deletions for Glioma Probes: 1p36/1q25 |19q13/19p13Disease(s): Oligodendroglioma Ratios of p:q signals are determined for each chromosome to account for sectioning artifact. Deletion status is reported for each…
FISH
ALK for NSCLC Probes: ALK (2p23)Disease(s): Non-small cell lung carcinoma (NSCLC)
FISH
Bladder Cancer Probes: +3 (Cen 3) | +7 (Cen 7) | p16 (9p21) | +17 (Cen 17)Disease(s): Bladder cancer
FISH
BRAF Rearrangement Probes: BRAF (7q34)Disease(s): Brain cancer, thyroid cancer, melanoma
FISH
DDIT3 (CHOP) Probes: DDIT3 (CHOP) (12q13)Disease(s): Myxoid-round cell liposarcoma (M/RCLS)
FISH
EGFR Amplification Probes: EGFR (7p11.2) | Centromere 7Disease(s): Brain, lung, colorectal, gastric, breast cancers
FISH
EWSR1 Probes: EWSR1 (22q12)Disease(s): Ewing sarcoma, primitive neuroectodermal tumor (PNET)
FISH
HER2 Breast Cancer Probes: HER2 (17q11.2-q12) | 17 (Cen 17Disease(s): Breast cancer
FISH
HER2 Breast Equivocal FISH Panel Probes: TP53 (17p13.1) | SMS Critical Region (SMSCR) (17p11.2) | Centromere 17 | RARA (17q21.1Disease(s): Breast cancerTesting is performed only on a global basis at this time.
FISH
HER2 Gastric & Non-Breast Probes: HER2 (17q11.2-q12) | 17 (Cen 17)Disease(s): Gastric cancer, gastroesophageal junction (GEJ) cancer, esophageal adenocarcinoma, and others
FISH
MDM2 Probes: MDM2 (12q15) | Centromere 12Disease(s): Liposarcoma
FISH
MET FISH Probes: MET (7q31) | Centromere 7Disease(s): Multiple solid tumor cancers including lung (NSCLC), gastric, esophageal, endometrial
FISH
MYCN (n-MYC) Amplification Probes: MYCN (2p24.3) | Centromere 2Disease(s): Brain cancer, neuroblastoma, alveolar rhabdomyosarcoma, small-cell lung cancer, prostate cancer.
FISH
NeoSITE™ BE Barrett's Esophagus FISH Panel Probes: MYC (8q24) | p16 (CDKN2A at 9p21) | HER2 (ERBB2 at 17q12) | ZNF217 (20q13) This 4-probe FISH assay is performed on cytology brushings from Barrett esophagus to determine patterns of…
FISH
NeoSITE™ Cervical FISH Panel Probes: TERC (3q26) | D5S630 (5p15) |CEN 7 (7p11.1-q11.1) | MYC (8q24) | ZNF217 (20q13)Disease(s): Cervical neoplasia, ASCUS, LSIL, HSIL, CIN, cervical cancer
FISH
NeoSITE™ Melanoma Probes: RREB1 (6p25) | MYC (8q24) | CDKN2A p16 (9p21) | Centromere 9 | CCND1 (11q13)Disease(s): MelanomaRead more about the NeoSITE Melanoma panel.
FISH
PDGFRA Amplification Probes: PDGFRA (4q12) | Centromere 4Disease(s): Brain cancer
FISH
PTEN Probes: PTEN (10q23) | GRID1 (10q23.2) | Centromere 10Disease(s): Prostate cancer, melanoma, squamous cell carcinoma of the head and neck (PTEN deletions) This test may be ordered separately or as…
FISH
RET FISH Probes: RET (10q11.2)Disease(s): Lung cancer, thyroid cancer
FISH
ROS1 Probes: ROS1 (6q22.1)Disease(s): Non-small cell lung carcinoma (NSCLC)
FISH
SS18 (SYT) Probes: SS18 (SYT) (18q11.2)Disease(s): Synovial sarcoma
FISH
DNA Ploidy/Cell Cycle Analysis – POC/Solid Tumors Available as a global test only. DNA stain propidium iodide (PI) is used to determine S-phase cell cycle fraction and DNA index as indicators of DNA ploidy. Products of conception (POC) and solid…
Flow Cytometry
Extended Leukemia/Lymphoma Panel - 31 markers Available as global and tech-only. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11b, CD11c, CD13, CD14, CD15, CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD41, CD45, CD56, CD64, CD71, CD117, CD138…
Flow Cytometry
Standard Leukemia/Lymphoma Panel - 24 markers Available as global and tech-only. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD13, CD14, CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD45, CD56, CD64, CD117, HLA-DR, kappa, and lambda.
Flow Cytometry
Pan-TRK Pan-TRK (clone EPR17341) is directed against the C-terminal region of TRK (tropomyosin receptor kinase) A, B, and C proteins, which are encoded by NTRK1, NTRK2, and NTRK3 genes respectively.  Pan-TRK…
Immunohistochemistry (IHC)
AAT Alpha-1-Antitrypsin (AAT) is useful in the study of inherited AAT deficiency, benign and malignant hepatic tumors and yolk sac carcinoma. Sensitivity and specificity of the results have made this…
Immunohistochemistry (IHC)
AFB Special stain. Ziehl-Neelsen Acid-Fast Bacilli Stain is used to detect the presence of acid-fast mycobacteria in tissue sections. Acid-fast techniques are of value in the detection of mycobacteria,…
Immunohistochemistry (IHC)
ACTH Anti-adrenocorticotropic hormone (ACTH) is a useful marker in the classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also…
Immunohistochemistry (IHC)
MSA Muscle Specific Actin (MSA) antibody recognizes the alpha and gamma isotypes of skeletal, cardiac, and smooth muscle cells. It is non-reactive with other mesenchymal cells and all epithelial cells…
Immunohistochemistry (IHC)
AFP Alpha-1-fetoprotein (AFP) is a 64 kD tumor-associated embryonal antigen produced by fetal liver, hepatocellular carcinoma, yolk sac tumor and several germ cell tumors of testicular and ovarian origin…
Immunohistochemistry (IHC)
Alcian Blue Special stain. Alcian blue is intended to identify weakly sulfated mucins in tissue samples.
Immunohistochemistry (IHC)
ALK (D5F3) VENTANA FDA approved ALK (D5F3) CDx Assay is intended for the qualitative detection of the anaplastic lymphoma kinase (ALK) protein in formalin-fixed, paraffin-embedded (FFPE) non-small cell lung…
Immunohistochemistry (IHC)
ALK-1 (for heme cases) The ALK1 (ALK1 cline) antibody labels normal human ALK protein and the NPM-ALK chimeric protein, and is a useful tool for the identification of the subgroup of anaplastic large-cell lymphomas (ALCL)…
Immunohistochemistry (IHC)
AR Androgen receptor (AR) is responsible for the regulation of the growth of the prostate epithelial cells. In untreated prostate carcinoma, AR positive cells are more likely to be responsive to…
Immunohistochemistry (IHC)
Arginase 1 Arginase 1 (ARG1), also known as liver arginase, is a binuclear manganese metalloenzyme. ARG1 is abundantly expressed in liver and represents a sensitive and specific marker of benign and malignant…
Immunohistochemistry (IHC)
BCA-225 This antibody recognizes a human breast carcinoma associated glycoprotein BCA-225 (220-225kD). This protein differs in size and distribution from other breast carcinoma antigens. It does not react…
Immunohistochemistry (IHC)
BCL2 B-cell lymphoma 2 (BCL2) was the first of the translocation-associated proteins to be identified in lymphoma. Most cases of follicular lymphoma have a [t(14;18)] translocation, resulting in BCL2…
Immunohistochemistry (IHC)
BerEP4 Ber-EP4 recognizes two glycoproteins of 34 and 49 kDa present on the surface and the cytoplasm of all epithelial cells except the superficial layers of squamous epithelial, hepatocytes and parietal…
Immunohistochemistry (IHC)
Beta Catenin Beta-catenin is an important regulator of cell–cell adhesion and embryogenesis. Mutations of beta-catenin could lead to some human cancers. Normal cells show membrane staining for beta-catenin, while…
Immunohistochemistry (IHC)
BG8 This antibody is specific for the Lewis Y (Type 2 Chain) carbohydrate antigen. Lewis Y has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular…
Immunohistochemistry (IHC)
BRAF V600E A monoclonal antibody (VE1) against mutant BRAF (V600E) permits fast assessment of the mutant protein expression throughout a tumor sample in hairy cell leukemia, some melanomas, and some thyroid…
Immunohistochemistry (IHC)
Breast Triple Stain (CK5 + p63 + CK 8/18) The combination of CK5 + P63 + CK8/18 (Breast Triple Stain) can be useful in distinguishing ductal carcinoma in situ (DCIS) from microinvasive breast carcinoma. This multiplex can decipher between a…
Immunohistochemistry (IHC)
CA125 CA125 reacts with most epithelial ovarian neoplasms of serous, endometrioid, clear cell and undifferentiated types. CA125 is a useful tumor marker for ovarian carcinomas; however, CA125 has also been…
Immunohistochemistry (IHC)
CA19.9 In normal tissues, the CA19.9 antigen has been demonstrated in ductal epithelium of the breast, kidney, salivary gland, sweat glands, respiratory epithelium of the lung, colon epithelium, pancreatic…
Immunohistochemistry (IHC)
Carbonic Anhydrase IX (CA IX) Carbonic anhydrase IX (CAIX) is a cell surface transmembrane protein, which is predominantly found in the gastrointestinal tract and gall bladder. The glandular regions of normal colon are reported…
Immunohistochemistry (IHC)
Calcitonin Calcitonin is secreted by thyroidal parafollicular cells of neuroectodermal origin, probably in response to hypercalcemia. The IHC demonstration of calcitonin is important: (1) For identification of…
Immunohistochemistry (IHC)
Caldesmon Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction. Two closely related variants of human caldesmon have been identified. The h-caldesmon variant (…
Immunohistochemistry (IHC)
Calretinin Calretinin is the most specific and reproducible positive marker of epithelial mesothelioma. Calretinin is a calcium-binding protein similar to S100 protein. It is found in the central and peripheral…
Immunohistochemistry (IHC)
CD10 CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is expressed in early lymphoid progenitors and normal germinal center cells. It is almost always present on the surface of…
Immunohistochemistry (IHC)
CD163 CD163 antigen is restricted in its expression to the monocytic/macrophage lineage. It is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and…
Immunohistochemistry (IHC)
CD31 CD31 is a 130kDa transmembrane glycoprotein that is shared by vascular lining cells, megakaryocytes and platelets. This marker is highly restricted to endothelial neoplasms among all tumors of the…
Immunohistochemistry (IHC)
CD34 CD34, a single chain transmembrane glycoprotein, is selectively expressed on human lymphoid and myeloid hematopoietic progenitor cells and endothelial cells. CD34 antibody labels many…
Immunohistochemistry (IHC)
CD4 CD4, a single chain transmembrane glycoprotein, is found on a T-cell subset (helper/inducer). It is also present on a variety of monocyte-derived cells, including Langerhans and other dendritic cells…
Immunohistochemistry (IHC)
CD44 The CD44 family of glycoproteins exists in a number of variant isoforms, including hematopoietic variant (CD44s) and epithelial cells variant (CD44v). While many human tumors express CD44, a positive…
Immunohistochemistry (IHC)
CD68 CD68 is an antibody directed against lysosomes. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and…
Immunohistochemistry (IHC)
CD99 CD99 (MIC2 gene product, E2) antigen is strongly expressed by Ewing sarcoma cells, primitive peripheral neuroectodermal tumors, and lymphoblastic leukemia/lymphoma.
Immunohistochemistry (IHC)
CDK4 Among cyclin/CDK proteins, CDK4 and cyclin D1 are the most frequently activated by somatic genetic alterations in multiple tumor types. CDK4 antibody assists in distinguishing atypical lipomatous…
Immunohistochemistry (IHC)
CDX2 CDX2 is an intestine specific transcription factor that regulates both the proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells…
Immunohistochemistry (IHC)
CEA (Mono) Carcinoembryonic antigen (CEA) is usually demonstrated as a linear labeling of the apical poles of cells lining the glandular lumen and occasionally as weak staining near the apex of normal colonic…
Immunohistochemistry (IHC)
CEA (Poly) Polyclonal carcinoembryonic antigen (CEA) antibody stains a larger percentage of cholangiocarcinomas compared to hepatocellular carcinomas. Approximately 95% of olangiocarcinomas are stained…
Immunohistochemistry (IHC)
Chromogranin A Chromogranin is present in several elements of the diffuse neuroendocrine system (DNES), including anterior pituitary, thyroid perifollicular C cells, parathyroid chief cells, pancreatic islet cells…
Immunohistochemistry (IHC)
Pan-Cytokeratin Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin, respectively, thus the combination of these two antibodies can be used to detect almost all human…
Immunohistochemistry (IHC)
CAM 5.2 Anti-Cytokeratin (CAM 5.2) has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 Kd. Cytokeratin 8 is present on secretory epithelia of…
Immunohistochemistry (IHC)
CK HMW (CK903/34BE12) CK903 (34betaE12) is a high molecular weight cytokeratin present in all squamous epithelium and their carcinomas. This antibody recognizes cytokeratins 1, 5, 10 and 14 that are found in complex…
Immunohistochemistry (IHC)
CK OSCAR Anti-cytokeratin clone OSCAR (CK OSCAR) demonstrates a broad spectrum of cytokeratin reactivity. In normal tissues, OSCAR is reactive with most epithelial types, including bile ducts and hepatocytes…
Immunohistochemistry (IHC)
CK17 Cytokeratin 17 (CK17) is an effective marker to distinguish myoepithelial cells from luminal epithelium of various glands (mammary, sweat, salivary, bronchial, tracheal, laryngeal, esophageal) and…
Immunohistochemistry (IHC)
CK19 Cytokeratin 19 (CK19) is a member of the type I acidic subfamily of keratins. It is expressed in various different human tissues. CK19 labels ductal and glandular epithelia, prostatic epithelia, and…
Immunohistochemistry (IHC)
CK20 Cytokeratin 20 (CK20) positivity is seen in the majority of adenocarcinomas of the colon, mucinous ovarian carcinomas, transitional cell, and Merkel cell carcinomas, and frequently in adenocarcinomas…
Immunohistochemistry (IHC)
CK5/6 D5/16 B4 clone of CK5/6 antibody reacts strongly with cytokeratins 5 and 6. Cytokeratin 5/6 have been found valuable for the distinction between low differentiated squamous cell carcinoma and…
Immunohistochemistry (IHC)
CK7 Cytokeratin 7 (CK7) antibody reacts with proteins that are found in most ductal, glandular and transitional epithelium of the urinary tract and bile duct epithelial cells. CK7 distinguishes between…
Immunohistochemistry (IHC)
cMET The cMET tyrosine kinase receptor, normally expressed by epithelial cells, is overexpressed and amplified in a variety of human tumors, including non-small cell lung carcinoma (NSCLC). High levels of…
Immunohistochemistry (IHC)
Collagen IV Collagen IV is a major constituent of the basement membranes along with laminins and enactins. In kidney, the antibody reacts with glomerular and tubular basement membranes, parts of the mesenchymal…
Immunohistochemistry (IHC)
Copper Stain Special stain.
Immunohistochemistry (IHC)
COX2 Cyclooxygenase-2 (COX-2) plays a role in tumorigenesis through stimulating epithelial cell proliferation, inhibiting apoptosis, stimulating angiogenesis, enhancing cell invasiveness, mediating immune…
Immunohistochemistry (IHC)
Inhibin Anti-Inhibin alpha is an antibody against a peptide hormone which has a demonstrated utility in differentiating between adrenocortical tumors and renal cell carcinoma. This antibody stains most…
Immunohistochemistry (IHC)
Desmin Desmin is an intermediate filament protein of both smooth and striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well as smooth muscle cells. Anti-desmin antibody is…
Immunohistochemistry (IHC)
DOG1 DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with Kit mutations the DOG1 antibody identified 11% more cases…
Immunohistochemistry (IHC)
DPC4 The gene DPC4 (deleted in pancreatic carcinoma 4, also called SMAD4) was identified in 18q21.3 This gene is frequently mutated and deleted in pancreatic carcinomas (55%) and less frequently (20 - 22…
Immunohistochemistry (IHC)
E-Cadherin E Cadherin is an adhesion protein that is expressed in cells of epithelial lineage. It stains positively in glandular epithelium, as well as adenocarcinomas of the lung, G.I. tract and ovary. It is…
Immunohistochemistry (IHC)
EGFR Epidermal Growth Factor Receptor (EGFR) overexpression can occur in a variety of tumor types, including breast, prostate, ovarian, brain, lung and predominantly squamous cell carcinomas. Tumors that…
Immunohistochemistry (IHC)
EGFR (E746-A750del specific) Epidermal Growth Factor Receptor (EGFR) is a 170 kDa transmembrane receptor tyrosine kinase that belongs to the HER/ErbB protein family. Somatic mutations in the tyrosine kinase domain of EGFR are…
Immunohistochemistry (IHC)
EGFR (L858R mutant specific) Epidermal Growth Factor Receptor (EGFR) is a 170 kDa transmembrane receptor tyrosine kinase that belongs to the HER/ErbB protein family. Somatic mutations in the tyrosine kinase domain of EGFR are…
Immunohistochemistry (IHC)
EMA Epithelial Membrane Antigen (EMA) antibody stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands and squamous epithelium. Hepatocellular carcinoma,…
Immunohistochemistry (IHC)
ER Estrogen Receptor (ER) belongs to a superfamily of nuclear hormone receptors and is expressed in about 85% of invasive breast cancers. There are two known isoforms of estrogen receptor, ERα and ERß.…
Immunohistochemistry (IHC)
ERCC1 The Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 1 (ERCC1) polypeptide is required for nucleotide excision repair (NER) of damaged DNA. Elevated levels of ERCC1…
Immunohistochemistry (IHC)
ERG ERG oncoprotein expression has been shown to be a highly specific marker for prostate cancer. Given the lack of ERG expression in a wide variety of normal epithelial tissues and tumors, detection of…
Immunohistochemistry (IHC)
Factor VIII RA Factor VIII-related antigen is a component of Factor VIII complex. Factor VIII-related antigen is one of the available immunohistochemical markers of endothelial cells. It has also been demonstrated…
Immunohistochemistry (IHC)
Factor XIIIa Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and…
Immunohistochemistry (IHC)
FLi-1 Friend leukemia integration (FLI1) is a nuclear transcription factor and has been reported as the first nuclear marker of endothelial differentiation. FLI1 labels hemangiomas, angiosarcomas, Kaposis…
Immunohistochemistry (IHC)
FOXP3 FOX P3 is expressed at a high level in CD25 positive/CD4 positive regulatory T cells, at a low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOX P3…
Immunohistochemistry (IHC)
FSH Follicle Stimulating Hormone (FSH) is a pituitary hormone involved in the maturation of ovarian follicles and estrogen secretion in females. In the pituitary gland, FSH is produced by gonadotrophs.…
Immunohistochemistry (IHC)
Galectin 3 Galectins are a structurally-related family of proteins; 14 different galectins have been characterized. They are cytoplasmic proteins and can be translocated into the nucleus. Gal-3 has been found…
Immunohistochemistry (IHC)
Gastrin Gastrin, a polypeptide hormone, occurs naturally in three forms: gastrin-14, gastrin-17 and gastrin-34. This antibody labels gastrin or gastrin-analogue producing cells in gastrin-secreting tumors…
Immunohistochemistry (IHC)
GATA3 GATA3 (GATA binding protein 3) is a member of the GATA family of transcription factors. Among several other roles, GATA3 is involved in luminal cell differentiation in the mammary gland and appears…
Immunohistochemistry (IHC)
GCDFP15 This antibody is specific to a 15kDa monomer protein called Gross Cystic Disease Fluid Protein-15 (GCDFP-15). GCDFP15 is expressed in apocrine epithelia, lacrimal, ceruminous and Moll’s glands, as…
Immunohistochemistry (IHC)
GFAP Glial Fibrillary Acidic Protein (GFAP) is the major protein found in astrocytes and its expression is evidence of astroglial origin and differentiation. Gliomas are the most common cerebral neoplasm…
Immunohistochemistry (IHC)
GH Growth Hormone (GH) is produced by the somatotroph cells in the pituitary. This marker is a useful in classification of pituitary tumors and the study of pituitary disease (acromegaly).
Immunohistochemistry (IHC)
HPL Human Placental Lactogen (HPL) is a polypeptide hormone synthesized in syncytiotrophoblastic cells of placenta and has been used as a tissue marker for certain trophoblastic tumors.
Immunohistochemistry (IHC)
GLUT1 Glucose transporter 1 (GLUT1) facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT-1 is expressed in many human tissues including those of the colon, lung,…
Immunohistochemistry (IHC)
Glypican-3 A useful marker to differentiate between benign (negative) and malignant (positive) liver diseases (HCCs).
Immunohistochemistry (IHC)
IDH1 IDH1 mutations are frequent genetic alterations in low-grade diffuse gliomas and secondary glioblastoma (70%). This alteration is observed in fewer than 10% of primary GBM cases. IDH1 IHC antibody is…
Immunohistochemistry (IHC)
HBME1 HBME1 is an anti-mesothelial monoclonal antibody that recognizes an unknown antigen on the microvilli of mesothelioma cells. It stains normal mesothelial cells as well as epithelial mesotheliomas in…
Immunohistochemistry (IHC)
H. Pylori This antibody reacts with H. pylori on the surface and in the cytoplasm of epithelial cells of stomach biopsies. Studies have shown that H. pylori plays an important role in the etiology of chronic…
Immunohistochemistry (IHC)
D240 D2 40 identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Anti-D2 40 has also been demonstrated to label lymphatic…
Immunohistochemistry (IHC)
Hepatitis B Core Antigen Hepatitis B virus belongs to the hepatovirus family and causes type B hepatitis. Hepatitis B virus is spherical in shape with a diameter of 42 nm. Core antigens are localized within the nuclei,…
Immunohistochemistry (IHC)
HHV8 Human Herpes Virus (HHV) 8 is the likely etiological agent of Kaposi’s sarcoma (KS), and is present in all cases. HHV 8 encodes a latent nuclear antigen (LANA) that is the product of the viral gene…
Immunohistochemistry (IHC)
HMB45 Antibody clone HMB45 recognizes a melanoma-specific antigen by reacting with melanoma cells, nevus cells and neonatal melanocytes. HMB45 is expressed on the majority of malignant melanoma cases as…
Immunohistochemistry (IHC)
Hepatitis B Surface Antigen Hepatitis B virus, belongs to the hepatovirus family, and causes type B hepatitis. It is spherical in shape with a diameter of 42 nm. It contains a 27 nm partially double stranded DNA core enclosed…
Immunohistochemistry (IHC)
HSV I/II This antibody cocktail reacts with Herpes Simplex Virus (HSV) type 1- or type 2-specific antigens and with antigens common to both types. The antibodies react with all the major glycoproteins present…
Immunohistochemistry (IHC)
HepPar1 Anti-Hepatocyte Specific Antigen (HepPar1) recognizes both benign and malignant liver derived tumors such as hepatoblastoma, hepatocellular carcinoma and hepatic adenoma. It recognizes both adult and…
Immunohistochemistry (IHC)
Glucagon Glucagon antibody is used for the identification of tumors and hyperplasias of pancreatic islets. This antibody labels A cells of the endocrine mammalian pancreas. It reacts with glucagon in a large…
Immunohistochemistry (IHC)
Ki67 Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cell cycle, while cells in the G0 (quiescent) phase are…
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Melan A (Mart1) Melan A (Mart1, Melanoma Antigen Recognized by T-cells 1), is a differentiation antigen that is expressed in melanocytes, most melanomas. Melan A recognizes a subcellular fraction found in…
Immunohistochemistry (IHC)
Mesothelin Mesothelin is a 40kDa cell surface glycoprotein selectively expressed by mesothelial cells and malignant mesotheliomas, as well as by non-mucinous ovarian carcinomas, breast carcinomas, pancreatic…
Immunohistochemistry (IHC)
MGMT MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme. MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents. It…
Immunohistochemistry (IHC)
MMR Panel by IHC (MLH1, MSH2, MSH6, PMS2) A well-defined subtype of colorectal cancer (CRC) is characterized by deficiencies in the mismatch repair (MMR) pathway. MMR status may impact prognosis and benefit of adjuvant chemotherapy. MLH1,…
Immunohistochemistry (IHC)
MOC31 Monoclonal antibody MOC31 recognizes a membrane glycoprotein of 40kDa present on epithelial cells but not on mesothelial cells. MOC31 reacts with most adenocarcinomas of various origins, typically…
Immunohistochemistry (IHC)
MUC1 Mucin 1 (MUC1) is a high molecular weight glycoprotein that is found on the apical surface of many glandular epithelia, including the gastrointestinal, respiratory, urinary, reproductive tracts and…
Immunohistochemistry (IHC)
MUC2 Mucin 2 (MUC2) expression is detected in human tissues such as normal colon, breast, prostate, and salivary gland, as well as in gastrointestinal, colonic, breast and prostate neoplasia. This…
Immunohistochemistry (IHC)
MUC5 Mucin 5 (MUC5) is expressed in gastric mucosa, and in gall bladder epithelium. MUC5 antibody is recommended for use as part of a panel of antibodies for the characterization of mucin expression and…
Immunohistochemistry (IHC)
Mucicarmine Special stain. Mucicarmine staining is used to identify epithelial mucins, namely acid mucopolysaccharides. Staining is useful to distinguishing mucin negative undifferentiated squamous cell lesions…
Immunohistochemistry (IHC)
MyoD1 Nuclear expression of myogenic differentiation 1 (MyoD1) is restricted to skeletal muscle tissue and has been demonstrated to be a sensitive marker of myogenic differentiation. The antibody strongly…
Immunohistochemistry (IHC)
Myogenin Expression of myogenin is restricted to cells of skeletal muscle origin. It is a useful marker for tumors of the muscle lineage, being strongly expressed in alveolar rhabdomyosarcomas.
Immunohistochemistry (IHC)
Myoglobin Myoglobin is found in skeletal and cardiac muscle but not in smooth muscle. Because myoglobin appears relatively late in the maturational sequence of striated muscle, it is typically undetectable…
Immunohistochemistry (IHC)
NF (Neurofilament) Neurofilaments (NFs) are the intermediate filaments of neurons and their processes. NFs are expressed in tumors of neural origin or tumors displaying neuronal differentiation, such as neuroblastoma,…
Immunohistochemistry (IHC)
NKX2.2 Homeobox protein NKX2.2 plays a critical role in neuroendocrine/glial differentiation. The NKX2.2 gene was recently identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma.…
Immunohistochemistry (IHC)
NSE (Neuron Specific Enolase) In normal tissue, most neurons and their axonal and dendritic processes stain strongly positive for Neuron Specific Enolase (NSE), with the exception of Purkinje cells. Schwann cells, cells of the…
Immunohistochemistry (IHC)
p21 p21 is a cyclin dependent protein kinase inhibitor and is a member of a family of proteins that functions to slow down cell division. p21 is found in t cells as they transitions from G1 phase to S…
Immunohistochemistry (IHC)
p27 p27 (KIP1) belongs to the family of cell cycle regulators that cause cell cycle arrest in G1 phase. p27 promotes apoptosis, plays a role in terminal differentiation of some tissues and mediates…
Immunohistochemistry (IHC)
p40 p40 antibody recognizes ΔNp63—a p63 isoform. It is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential…
Immunohistochemistry (IHC)
p53 The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results in inactivation of its tumor suppressor function…
Immunohistochemistry (IHC)
Pan Melanoma (S100 + Melan A + Tyrosinase) The Pan Melanoma staining combination increases sensitivity for melanomas. Since many skin biopsies are small, the triple stain conserves valuable tissue while saving time. Melan A (brown cytoplasmic…
Immunohistochemistry (IHC)
Pan Melanoma/Ki67 Pan Melanoma/Ki67 serves as a tool to identify the proliferation rate of melanocytic lesions. A high Ki67 rate of a melanocytic lesion raises the possibility of malignancy.
Immunohistochemistry (IHC)
PAX8 The PAX8 gene is a member of the paired box (PAX) family of transcription factors. This family plays critical roles during fetal development and cancer growth. PAX8 is involved in kidney cell…
Immunohistochemistry (IHC)
PD-L1 28-8 FDA (OPDIVO®) PD-L1 IHC 28-8 pharmDx is a qualitative immunohistochemical assay using Monoclonal Rabbit Anti-PD-L1, clone 28-8 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-…
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
PgR Progesterone Receptor (PR) belongs to a superfamily of nuclear hormone receptors. Estrogen Receptor (ER) induces PR expression, therefore, PR status serves as an indicator of an intact ER pathway.…
Immunohistochemistry (IHC)
pHistone H3 (PHH3) Phosphohistone H3 (PHH3) is a marker of cells in the late G2-M phase of the cell cycle. It is not expressed in apoptotic cells which may be confused with mitotic figures on a routine H&E stained…
Immunohistochemistry (IHC)
PLAP Normally human Placental Alkaline Phosphatase (PLAP) is produced by syncytiotrophoblasts after the twelfth week of pregnancy. PLAP is expressed by both malignant somatic and germ cell tumors. PLAP…
Immunohistochemistry (IHC)
PMS2 PMS2, also known as PMS1 protein homologue 2, is a DNA mismatch repair (MMR) protein. The PMS2 protein forms a heterodimer with the MLH1 protein which is then activated in the presence of ATP; this…
Immunohistochemistry (IHC)
Pneumocystis Carinii ( Jiroveci) This antibody is specific to P. carinii (P. Jiroveci). It stains P. carinii distinctly. The staining pattern is visualized as homogeneous rings corresponding to individual cyst walls. In addition,…
Immunohistochemistry (IHC)
NeoTYPE® Head & Neck Tumor Profile The NeoTYPE Head & Neck Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
HPV DNA Tissue Testing HPV DNA Tissue Testing is peformed on FFPE tissue. It uses PCR and fragment analysis for qualitative detection and genotyping of human papillomavirus (HPV) low risk types 6/11 and high risk types 16…
Molecular
S100 S100 belongs to the family of calcium binding proteins. Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign melanocytic lesions, melanomas and their metastases. S100…
Immunohistochemistry (IHC)
SAT B2 SATB2 stains colonic and osteogenic cells and their neoplasms.
Immunohistochemistry (IHC)
SF1 SF1 is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF1 is highly valuable…
Immunohistochemistry (IHC)
SMMHC Smooth Muscle Myosin, Heavy Chain (SMMS-1) is an antibody to smooth muscle myosin, heavy chain that reacts with human visceral and vascular smooth muscle cells. The antibody also reacts with human…
Immunohistochemistry (IHC)
Smoothelin Smoothelin is a novel cytoskeletal protein that reacts with the 59 kDa and 100 kDa proteins corresponding to Smoothelin A and B, respectively, which are exclusively found in smooth muscle cells (SMC…
Immunohistochemistry (IHC)
SOX10 SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is also a useful marker in detecting both the in situ and invasive components of desmoplastic…
Immunohistochemistry (IHC)
Synaptophysin Antibody to synaptophysin reacts with neuroendocrine neoplasms of neural as well as epithelial types. In combination with chromogranin A and NSE antibodies, the antibody to synaptophysin is very…
Immunohistochemistry (IHC)
TFE3 Overexpression of TFE3 is a sensitive and specific marker of Xp11 translocation in renal cell carcinomas. TFE3 is also expressed in alveolar soft part sarcoma the hallmark of which is a chromosomal…
Immunohistochemistry (IHC)
Thrombomodulin (TM) Thrombomodulin (TM) is a plasma membrane-related glycoprotein that has anticoagulant activity. TM antigen is found in several cell types, including megakaryocytes, mesangial cells, synovial cells,…
Immunohistochemistry (IHC)
TLE1 Expression of the transducing-like receptor (TLE) genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state. TLE1…
Immunohistochemistry (IHC)
Trichrome Special stain. Trichrome stains are frequently used to differentiate between collagen and smooth muscle in tumors and to identify increases in collagenous tissue in diseases such as cirrhosis of the…
Immunohistochemistry (IHC)
Tryptase This antibody labels a mast cell tryptase. It will also show reactivity to basophils, but to a lesser degree.
Immunohistochemistry (IHC)
TTF1 Thyroid Transcription Factory (TTF1) is found only in thyroid and thyroid tumors regardless of histologic type, as well as in lung carcinomas, including adenocarcinomas, non-small cell carcinomas,…
Immunohistochemistry (IHC)
Tyrosinase Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. Mutations of the tyrosinase gene occur in various forms of albinism.…
Immunohistochemistry (IHC)
Vimentin Vimentin is the major intermediate filament in a variety of mesenchymal cells, including endothelial cells, all fibroblastic cells, macrophages, Sertoli cells, melanocytes, lymphocytes and ovarian…
Immunohistochemistry (IHC)
Warthin Starry Special stain. Warthin Starry stain is intended to identify Helicobacter pylori in tissue samples.
Immunohistochemistry (IHC)
WT1 Wilms tumor susceptibility gene 1 protein (WT1) has diagnostic utility in the distinction of mesothelioma from adenocarcinoma in tissue sections of pleural tumors. WT1 diffusely stains most ovarian…
Immunohistochemistry (IHC)
CMV In situ hybridization for detection of cytomegalovirus (CMV) RNA.
In Situ Hybridization (ISH)
EBER This probe set labels all latent EBV-infected cells, including EBV-positive lymphoblastoid cell lines and EBV infected B-cell immunoblasts in infectious mononucleosis. It also reacts with EBV-…
In Situ Hybridization (ISH)
Uroplakin II Uroplakin II is a 15 kDa protein component of urothelial plaques. Uroplakin II mRNA was found in both bladder cancer tissues and peripheral blood of patients with primary and metastatic urothelial…
Immunohistochemistry (IHC)
PD-L1 SP263 FDA (IMFINZI™) The VENTANA PD-L1 (SP263) assay is an FDA-approved complementary diagnostic IHC test for PD-L1 status in patients with locally advanced or metastatic urothelial carcinoma (mUC) who are being…
Immunohistochemistry (IHC)
Mammaglobin Mammaglobin is a breast-associated glycoprotein. In normal breast tissue, this antibody labels breast ductal and lobular epithelial cells. In tumor cells, they are reactive with all types of breast…
Immunohistochemistry (IHC)
p120 Catenin P120 Catenin is a tyrosine kinase which binds to E-cadherin within the cell membrane. It is detectable in the cell membranes of a wide variety of cells, but predominates in virtually all types of…
Immunohistochemistry (IHC)
HER2 Dual ISH The FDA approved Ventana Medical Systems’ (Ventana) INFORM HER2 Dual ISH DNA Probe set is intended to determine HER2 gene status by enumeration of the ratio of theHER2 gene to Chromosome 17 in…
In Situ Hybridization (ISH)
NeoTYPE® Breast Tumor Profile The NeoTYPE Breast Tumor Profile analyzes 28 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all…
Molecular
NeoTYPE® Discovery Profile for Solid Tumors This profile analyzes 334 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary interpretation of…
Molecular
TOP2A Probes: TOP2A (17q21-q22) | Cen 17 (17p11.1-q11.1)Disease(s): Breast cancerNote: Available as a global test only.
FISH
LH Luteinizing Hormone (LH) is a tropic hormone that modulates the secretory activity of other endocrine glands. It is produced in the anterior hypophysis of the pituitary gland. LH antibody is useful…
Immunohistochemistry (IHC)
NeuN NeuN is a sensitive and specific marker of neuronal differentiation in brain tumors.
Immunohistochemistry (IHC)
Olig2 Olig2, a transcription factor, is involved in oligodendroglial specification. Olig2 expression has been reported in most glial tumors, such as oligodendrogliomas and astrocytomas. Olig2 is negative…
Immunohistochemistry (IHC)
NeoTYPE® Liver/Biliary Tumor Profile The NeoTYPE Liver/Biliary Tumor Profile analyzes 29 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below.  Test orders include summary interpretation of…
Molecular
Prolactin Prolactin is a growth factor secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin antibody is useful in the identification…
Immunohistochemistry (IHC)
NeoTYPE® Melanoma Profile The NeoTYPE Melanoma Tumor Profile analyzes 22 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
SOX2 SOX2 stains all embryonal carcinomas and is highly specific for squamous cell carcinoma.
Immunohistochemistry (IHC)
NeoTYPE® Other Solid Tumor Profile This profile analyzes 29 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide…
Molecular
TSH Thyroid Stimulating Hormone (TSH) is a pituitary hormone of 28 kDa that stimulates thyroid growth and production of thyroid hormones. This antibody labels thyrotropic cells of the pituitary and may…
Immunohistochemistry (IHC)
NeoTYPE® Brain Tumor Profile The NeoTYPE Brain Tumor Profile analyzes 48 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include summary…
Molecular
NeoTYPE® Precision Profile for Solid Tumors This Profile analyzes 51 biomarkers through a combination of next-generation sequencing (NGS) and IHC as listed below. Test orders include summary interpretation of all results to help guide…
Molecular
ATRX Mutation Analysis Bi-directional Sanger sequencing of ATRX is performed using PCR primers designed to target hotspot mutations in exons 8-10, 12-15, 17, 18, 21, 22, 26, 30-32, and 35.
Molecular
EGFRvIII Analysis The EGFRvIII Analysis test is a real-time quantitative RT-PCR assay that is capable of detecting the EGFRvIII mutation that results from an inframe deletion of 801 base pairs spanning exons 2-7 of…
Molecular
ATRX ATRX mutations predominantly occur in grade II/III astrocytoma and secondary glioblastoma multiforme (GBM) brain tumors. ATRX loss defines a subgroup of astrocytic tumors with a favorable prognosis.
Immunohistochemistry (IHC)
p16 p16 (p16 -INK4a, p16-MTS1, inhibitor of CDK4) is the product of the CDKN2 gene. It inhibits the progression of the cell cycle through the G1 phase. p16 is a candidate tumor suppressor, whose gene is…
Immunohistochemistry (IHC)
BRAF Mutation Analysis Bi-directional sequencing of exon 15 of the BRAF gene, which includes qualitative detection of V600 mutations E, K, D, and others, plus other significant exon 15 mutations.  For solid tumors, tumor…
Molecular
NeoTYPE® Cervical Tumor Profile The NeoTYPE Cervical Tumor Profile analyzes 27 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all…
Molecular
Comprehensive Hereditary Cancer Panel Next-gen sequencing of all coding regions and intron-exon boundaries is performed concurrently for the following 73 genes: AKT1, APC, ATM, ATR, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4,…
Molecular
MSH2 Human mismatch repair protein 2 (MSH2) is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the…
Immunohistochemistry (IHC)
DNMT3A Mutation Analysis Bi-directional sequencing of exon 26, a mutation hotspot region containing R882 and other mutations. In hematological disease, testing may be performed on plamsa to increase sensitivity. For solid…
Molecular
EGFR Mutation Analysis Bi-directional sequencing of exons 18-21 of the EGFR gene for detection of EGFR-activating mutations and TKI resistance mutations (including T790M) in these exons. Tumor enrichment is performed…
Molecular
MSH6 Mismatch repair (MMR) genes results in failure to repair errors in repetitive sequences that occur during DNA replication. The defects in DNA repair pathways have been related to tumor carcinogenesis…
Immunohistochemistry (IHC)
Villin This antibody recognizes villin, a cytoskeletal filament protein of 58 kDa found in human renal epithelial cells. Villin antibody is useful for the study of gastrointestinal cells in normal and tumor…
Immunohistochemistry (IHC)
GNAS Mutation Analysis Bi-directional sequencing of exons 8 and 9 of the GNAS gene to detect mutation hot spots in codons R201 and Q227.
Molecular
NeoTYPE® Colorectal Tumor Profile The NeoTYPE  Colorectal Tumor Profile analyzes 29 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include…
Molecular
HRAS Mutation Analysis Bi-directional sequencing of HRAS exons 2 and 3 which includes sites of common activating mutations in codons 12, 13, 59 and 61.
Molecular
IDH1 & IDH2 Mutation Analysis Bi-directional sequencing of the exon 4 mutation hotspot regions in both the IDH1 and IDH2 genes. IDH1 and IDH2 are analyzed concurrently. In hematological disease, testing may be performed on plasma…
Molecular
RAS/RAF Panel The RAS/RAF Panel is an NGS-based assay performed by sequencing the entire coding region (full gene) of BRAF, HRAS, KRAS and NRAS genes. The panel reports mutations detected in the full gene…
Molecular
NeoTYPE® Endometrial Tumor Profile The NeoTYPE Endometrial Tumor Profile analyzes 28 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
X/Y FISH for Molar Pregnancy Probes: Centromere X | Centromere YNote: Testing is performed only on a global basis at this time.Disease(s): Molar pregnancy (hydatidiform mole), partial mole, triploidy
FISH
MLH1 MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. During DNA replication, strand misalignment can occur resulting in…
Immunohistochemistry (IHC)
KIT (c-KIT) Mutation Analysis Bi-directional sequencing of KIT exons 8, 9, 11, 13 and 17 for detection of activating mutations including the common mutation D816V. For solid tumors, tumor enrichment is performed before extraction…
Molecular
MUC6 MUC6 is expressed mucopeptic neck cells and pyloric glands of the gastric mucosa. MUC6 antibody is recommended for use as part of a panel of antibodies in differentiation of gastric cancer.
Immunohistochemistry (IHC)
KRAS Exon 4 Mutation Analysis Bi-directional sequencing of exon 4 of the KRAS gene corresponding to amino acids  R97 through Q150.  Codon 117 and 146 mutations are detected. For solid tumors, tumor enrichment is performed before…
Molecular
KRAS Mutation Analysis Bi-directional sequencing of exons 2 and 3 of the KRAS gene. High-sensitivity sequencing is used for enhanced detection of mutations in codons 12, 13, 59, and 61.  For solid tumors, tumor enrichment…
Molecular
MET (c-MET) Mutation Analysis Bi-directional Sanger sequencing of MET is performed using PCR primers designed to target hotspot mutations in exons 14, 16, 17 and 19.
Molecular
MGMT Promoter Methylation Analysis Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the MGMT gene promoter. Percentage of methylated DNA (compared to total DNA) is reported for positive…
Molecular
NeoTYPE® Esophageal Tumor Profile The NeoTYPE Esophageal Tumor Profile analyzes 28 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include…
Molecular
MLH1 Promoter Methylation Analysis This assay is performed on tumor tissue to detect hypermethylation of the MLH1 gene promoter. Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the…
Molecular
NeoTYPE® Gastric Tumor Profile The NeoTYPE Gastric Tumor Profile analyzes 28 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary…
Molecular
Microsatellite Instability Analysis (MSI) PCR and fragment analysis of paired normal and tumor tissue to determine microsatellite instability (MSI) at the standard five NCI-recommended loci. Positive results are reported as MSI-high (at…
Molecular
PD-L1 22C3 FDA (KEYTRUDA®) for Gastric/GEA PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
NeoARRAY™ SNP/Cytogenetic Profile The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage available, this test employs an enhanced SNP…
Molecular
RCC1 In normal kidney, renal cell carcinoma (RCC1, gp200) is localized along the brush border of the proximal tubule. In other normal tissues, RCC is also localized along the luminal surfaces of breast…
Immunohistochemistry (IHC)
Glutamine Synthetase Glutamine synthetase (GS) is strongly expressed in a majority of hepatocellular carcinoma, including cases of early HCC and low grade HCC.
Immunohistochemistry (IHC)
Napsin A Napsin A has a specific function in normal alveolar epithelium and is proposed to play a role in the proteolytic processing of surfactant precursors. Napsin A is reported to be predominantly…
Immunohistochemistry (IHC)
PD-L1 22C3 FDA (KEYTRUDA®) for NSCLC PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
ROS1 ROS1 gene rearrangements are reported in 1% to 2% of lung adenocarcinomas and are associated with a response to the multi-targeted tyrosine kinase inhibitor crizotinib. ROS1 rearrangement can be…
Immunohistochemistry (IHC)
Surfactant Pulmonary surfactant apoproteins play essential roles in keeping alveoli from collapsing at the end of expiration. SP-A is located mainly in type II pneumocytes and has been demonstrated in…
Immunohistochemistry (IHC)
NeoTYPE® Lung Tumor Profile The NeoTYPE Lung Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include summary…
Molecular
ALK Mutation Analysis Bi-directional Sanger sequencing of ALK is performed using PCR primers designed to target hotspot mutations in exons 23 and 25.
Molecular
NeoLAB™ Solid Tumor Monitor - Liquid Biopsy The NeoLAB™ Solid Tumor Monitor is a blood test that uses cell-free circulating tumor DNA (ctDNA) or RNA in combination with next-generation sequencing (NGS) to detect mutations in the following 48…
Molecular
NGS Comprehensive Sarcoma Fusion Profile The NGS Comprehensive Sarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect 134 different translocations relevant in sarcomas in the genes ALK, CAMTA1, CCNB3, CIC,…
Molecular
NGS Ewing Sarcoma Fusion Profile The NGS Ewing Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations relevant in Ewing's sarcoma in the gene EWSR1.
Molecular
NGS Non-Ewing Sarcoma Fusion Profile The NGS Non-Ewing Sarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations unrelated to Ewing's sarcoma in the genes ALK, CAMTA1, CCNB3, CIC, EPC1…
Molecular
NGS Pediatric Sarcoma Fusion Profile The NGS Pediatric Sarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations related to pediatric sarcomas in the genes ALK, EWSR1, FUS, GLI1, NTRK3…
Molecular
NGS Rhabdomyosarcoma Fusion Profile The NGS Rhabdomyosarcoma Fusion Profile is a targeted next-generation sequencing panel that can detect various translocations related to rhabdomyosarcoma in the genes FOXO1, NCOA2, and TFE3.
Molecular
NTRK & RET NGS Fusion Profile The NTRK & RET NGS Fusion Profile is an RNA-based next-generation sequencing panel that detects translocations and fusions of the genes NTRK1, NTRK2, NTRK3 and RET with known and novel fusion…
Molecular
NOTCH1 Mutation Analysis Bi-directional sequencing of exons 26, 27, and 34 is performed for detection of sequence variant mutations. Testing can be performed on plasma when adequate leukemic cells are not available.
Molecular
NRAS Mutation Analysis Bi-directional sequencing of NRAS exons 2 and 3 which includes sites of common activating mutations in codons 12, 13, 59, and 61. Testing is approved for specimens from the state of New York.
Molecular
PDGFRa Mutation Analysis Bi-directional sequencing of exons 12 and 18 of the PDGFRA (platelet-derived growth factor alpha) gene. These exons are mutation hotspots that account for the majority of PDGFRA mutations detected in…
Molecular
PIK3CA LDT Mutation Analysis by Sequencing Bi-directional sequencing of PIK3CA exons 1, 9, and 20 which are the most commonly-mutated regions of the gene.
Molecular
PTEN Mutation Analysis Bi-directional sequencing of all exons (1-9) of the PTEN gene. For solid tumors, enrichment is performed before extraction. This assay does not detect large deletions.
Molecular
EGFR T790M Germline Mutation Analysis Bidirectional sequence analysis of EGFR exon 20 in peripheral blood for detection of T790M germline mutation. Note: Patient and physician or genetic counselor signatures on the NeoGenomics Consent…
Molecular
MET Exon 14 Deletion Analysis MET Exon 14 Deletion Analysis is performed by real-time RT-PCR. The assay is designed to detect alternative splice junctions that lead to exon-skipping (deletion) of exon 14 of the gene MET. Note:…
Molecular
STAT3 Mutation Analysis Bi-directional sequencing of STAT3 exons 13-21 encompassing the DNA binding and SH2 domains.
Molecular
TP53 Mutation Analysis Bi-directional sequencing of TP53 exons 4-9.
Molecular
NeoLAB™ EGFR T790M - Liquid Biopsy The NeoLAB EGFR T790M - Liquid Biopsy test is a sequencing based assay that can detect the EGFR T790M mutation in plasma with high sensitivity (0.1%) using cell-free circulating tumor DNA (cfDNA).
Molecular
UGT1A1 Genotyping Lengths of the TA repeat polymorphism in the promoter region of the UTG1A1 gene are determined by fragment analysis using capillary electrophoresis. The alleles detected include the common normal…
Molecular
BAP1 BAP1 IHC stain is a tool for detection of BAP1 mutations with subsequent inactivation. Loss of BAP1 by IHC is 100% specific for malignant mesothelioma in the context of mesothelioma vs. mesothelial…
Immunohistochemistry (IHC)
CDKN2A (p16) Deletion for Mesothelioma Probes: CDKN2A (p16) (9p21) | Centromere 9Disease(s):  Mesothelioma
FISH
NeoTYPE Liposarcoma Fusion Profile The NeoTYPE Liposarcoma Fusion Profile combines next-generation sequencing to detect translocations in the genes EWSR1, FUS, HMGA2, and PLAG1 with FISH testing for MDM2 to detect amplifications…
Molecular
Oncomine™ Dx Target Test The Oncomine Dx Target Test is a next-gen sequencing assay designed to detect variants in 23 genes associated with non-small cell lung cancer (NSCLC). Abnormalities targeted are ROS1 gene fusions and…
Molecular
NeoTYPE® Ovarian Tumor Profile The NeoTYPE Ovarian Tumor Profile analyzes 29 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary…
Molecular
HER2 Breast This test uses the Ventana PATHWAY anti-HER-2/neu antibody (clone 4B5) for the semi-quantitative detection of HER-2 antigen in sections of FFPE normal and neoplastic tissue. The test is FDA-approved…
Immunohistochemistry (IHC)
TOPO1 Topoisomerase I (TOPO1)  is essential nuclear enzyme for replication and transcription during cell reproduction and DNA repair. Upregulation of TOPO1 increases with disease stage in colorectal and…
Immunohistochemistry (IHC)
Insulin Insulin is composed of a and b chains connected through the C-peptide. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as a marker of islet cell tumor…
Immunohistochemistry (IHC)
S100p Expression of S100P, a member of the S100 family, is increased in a number of tumors, including pancreas, lung, breast, and ovary carcinomas. S100P can be seen in many pancreatic ductal carcinoma,…
Immunohistochemistry (IHC)
TERT Promoter Mutation Analysis Bi-directional Sanger sequencing is performed using PCR primers designed to target mutations in the promoter region of TERT.
Molecular
Somatostatin Somatostatin is a useful marker of D-cells of pancreatic islet cells. D-cells are used to identify hyperplasia of the pancreatic islets. Most of these tumors are malignant, giving rise to…
Immunohistochemistry (IHC)
NeoTYPE® Pancreas Tumor Profile The NeoTYPE Pancreas Tumor Profile analyzes 29 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
NKX3.1 NKX3.1 is a protein encoded by the NKX3.1 gene located on chromosome 8. NKX3.1 protein has been found to be positive in the vast majority of primary prostatic adenocarcinomas. NKX3.1 stains nuclei in…
Immunohistochemistry (IHC)
P501S P501S protein, also called the prostein, is a type IIIa plasma membrane protein which is exclusively expressed in cells of normal and malignant prostate. P501S expression has not been detected in…
Immunohistochemistry (IHC)
P504S Expression of P504S protein, or Alpha-methylacyl-CoA Racemase (AMACR), is found in prostatic adenocarcinoma but not in benign prostatic tissue. It has also been found to stain premalignant lesions of…
Immunohistochemistry (IHC)
STAT6 STAT6 is a highly sensitive and specific immunohistochemical marker for solitary fibrous tumor (SFT) and can be helpful to distinguish this tumor type from histologic mimics.
Immunohistochemistry (IHC)
MUC4 MUC4 is useful in the identification of low-grade fibromyxoid sarcoma (LGFMS) and sclerosing epithelioid fibrosarcoma.
Immunohistochemistry (IHC)
Prostate Triple Stain The combination of p63 + CK HMW + P504S (PIN-4 cocktail) can be extremely useful for diagnosing prostatic intraepithelial neoplasia (PIN) and/or prostate carcinoma, especially in difficult cases with…
Immunohistochemistry (IHC)
PSA Prostate specific antigen (PSA) is a glycoprotein with a molecular weight of 33-34kDa. It is restricted to the cytoplasm of acinar and ductal epithelia of normal, benign or malignant prostate tissue…
Immunohistochemistry (IHC)
PSAP/HPAP Prostate specific acid phosphatase/human prostatic acid phosphatse (PSAP/HPAP) is a 100kDa glycoprotein present in high concentration in the prostate gland and its secretions. PSAP is specific to the…
Immunohistochemistry (IHC)
PSMA Prostate specific membrane antigen (PSMA) is a 750 amino acid type II membrane glycoprotein with folate hydrolase and neuropeptidase activity. PSMA is expressed in normal and malignant prostatic…
Immunohistochemistry (IHC)
NRAS Exon 4 Mutation Analysis Bi-directional sequencing of NRAS exon 4 is performed using PCR primers designed to target hotspot mutations in codons 117 and 146, among other regions in exon 4. Testing is available separately or…
Molecular
HOXB13 Genotyping This test is performed on a patient's blood specimen to look for germline genetic variants. The method is bi-directional sequencing of exons 1 and 2 of the HOXB13 gene for detection of the G84E…
Molecular
INI1 Lack of nuclear expression of INI1 is characteristic of malignant rhabdoid tumors and epithelioid sarcomas.
Immunohistochemistry (IHC)
RRM1 RRM1 is crucial for DNA synthesis and damage repair. High levels of RRM1 are associated with G2 cell cycle arrest and increased apoptosis in vitro.
Immunohistochemistry (IHC)
Androgen Receptor Mutation Analysis Bi-directional Sanger sequencing of the gene Androgen Receptor is performed using PCR primers designed to target hotspot mutations in exons 4, 5 and 8.
Molecular
HSD3B1 Genotyping Bi-directional Sanger sequencing is performed to detect the HSD3B1 (1245A>C) single nucleotide polymorphism (SNP). Inheritance of the HSD3B1 (1245C) allele, which enhances dihydrotestosterone…
Molecular
NeoTYPE® GI Predictive Profile The NeoTYPE GI Predictive Profile analyzes 9 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below.  Test orders include summary…
Molecular
PTH Parathyroid hormone (PTH) is expressed in normal parathyroid, parathyroid adenomas and primary and secondary hyperplasia of parathyroid. This antibody is useful in the differential diagnosis of…
Immunohistochemistry (IHC)
Thyroglobulin (TGB) This antibody labels thyroglobulin (TGB) in follicular epithelial cells of the thyroid and colloid. Thyroglobulin antibody is useful in positive identification of thyroid carcinomas of the papillary…
Immunohistochemistry (IHC)
NeoTYPE® Thyroid Profile The NeoTYPE® Thyroid Tumor Profile analyzes 21 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include…
Molecular
PPM1D Mutation Analysis PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent 1D) Mutation Analysis is performed by next-generation sequencing (NGS) of all coding regions of the PPM1D gene. Germline and somatic mutation testing…
Molecular
INSM1 INSM1 is a transcription factor that is a sensitive and specific marker for neuroendocrine tumors.  It is a nuclear stain, and is as good if not better than synaptophysin and is superior to…
Immunohistochemistry (IHC)
PD-L1 22C3 FDA (KEYTRUDA®) for Cervical PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
BCL10 BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It is also a substrate for MALT1. Mutations in the gene can lead to…
Immunohistochemistry (IHC)
NGFR Nerve Growth Factor Receptor (NGFR), also known as P75NTR or CD271, is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. NGFR is expressed mainly in Schwann cells and…
Immunohistochemistry (IHC)
Amyloid A & Amyloid P Amyloid A and P react with amyloid deposits in many tissues. When accompanied by Congo Red, Amyloid A and P can be used to distinguish primary and secondary amyloidosis. Because these stains are…
Immunohistochemistry (IHC)
PD-L1 SP142 FDA (TECENTRIQ®) for NSCLC The VENTANA PD-L1 (SP142) Assay is a qualitative immunohistochemical assay using rabbit monoclonal anti-PD-L1 clone SP142 intended for use in the assessment of the PD-L1 protein in formalin-fixed,…
Immunohistochemistry (IHC)
PD-L1 SP142 FDA (TECENTRIQ®) for Urothelial Carcinoma The VENTANA PD-L1 (SP142) Assay is a qualitative immunohistochemical assay using rabbit monoclonal anti-PD-L1 clone SP142 intended for use in the assessment of the PD-L1 protein in formalin-fixed,…
Immunohistochemistry (IHC)
CancerTYPE ID® with reflex to NeoTYPE® Cancer Profile CancerTYPE ID is a proprietary molecular cancer classifier used to identify unknown or unclear tumor types and subtypes in patients with metastatic cancer. When ordered through NeoGenomics,…
Molecular
PD-L1 22C3 FDA (KEYTRUDA®) for Urothelial Carcinoma PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
NTRK NGS Fusion Profile The NTRK NGS Fusion Profile is an RNA-based next-generation sequencing panel that detects translocations and fusions of the Neurotrophic Tropomyosin-Related Kinase (NTRK) genes NTRK1, NTRK2, and…
Molecular
Lung NGS Fusion Profile The Lung NGS Fusion Profile is an RNA-based next-generation sequencing panel that detects translocations and fusions of the genes ALK, NTRK1, NTRK2, NTRK3, RET and ROS1 with known and novel fusion…
Molecular
Albumin RNA ISH Albumin RNA ISH is a sensitive and specific tool for distinguishing primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma from metastatic adenocarcinoma to the liver or carcinoma of…
In Situ Hybridization (ISH)
NUT Expression of nuclear protein in testis (NUT) is generally confined to the germ cells of the testis and ovary. NUT midline carcinomas are aggressive tumors with non-diagnostic morphology that…
Immunohistochemistry (IHC)
PD-L1 SP142 FDA (TECENTRIQ®) for TNBC (Breast) The VENTANA PD-L1 (SP142) Assay is a qualitative immunohistochemical assay using rabbit monoclonal anti-PD-L1 clone SP142 intended for use in the assessment of the PD-L1 protein in formalin-fixed,…
Immunohistochemistry (IHC)
PIK3CA CDx Mutation Analysis by PCR PIK3CA CDx Mutation Analysis by PCR is an FDA-approved qualitative companion diagnostic assay performed on DNA extracted from FFPE breast tissue to detect 11 mutations in exons 7, 9, and 20 of the…
Molecular
FGFR CDx Molecular Analysis FGFR CDx Molecular Analysis is a qualitative RT-PCR assay, FDA-approved for detection of four point mutations in the FGFR3 gene (p.R248C, p.S249C, p.G370C and p.Y373C) and two FGFR3 fusions (FGFR3:…
Molecular
NeoTYPE® GIST and Soft Tissue Tumor Profile The NeoTYPE® GIST/Soft Tissue Tumor Profile analyzes 35 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation…
Molecular
PD-L1 22C3 FDA (KEYTRUDA®) for HNSCC (Head & Neck) PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded…
Immunohistochemistry (IHC)
BRCA1/2 Mutation Analysis for Tumors BRCA1 and BRCA2 mutation analysis is performed by next-generation sequencing of all coding exons of the BRCA1 and BRCA2 genes to detect point mutations and small insertions/deletions. This test does…
Molecular