Displaying 1 - 51 of 51 tests
p21 p21 is a cyclin dependent protein kinase inhibitor and is a member of a family of proteins that functions to slow down cell division. p21 is found in t cells as they transitions from G1 phase to S…
Immunohistochemistry (IHC)
p27 p27 (KIP1) belongs to the family of cell cycle regulators that cause cell cycle arrest in G1 phase. p27 promotes apoptosis, plays a role in terminal differentiation of some tissues and mediates…
Immunohistochemistry (IHC)
p40 p40 antibody recognizes ΔNp63—a p63 isoform. It is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential…
Immunohistochemistry (IHC)
p53 The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results in inactivation of its tumor suppressor function…
Immunohistochemistry (IHC)
pHistone H3 (PHH3) Phosphohistone H3 (PHH3) is a marker of cells in the late G2-M phase of the cell cycle. It is not expressed in apoptotic cells which may be confused with mitotic figures on a routine H&E stained…
Immunohistochemistry (IHC)
MET FISH Probes: MET (7q31) | Centromere 7Disease(s): Multiple solid tumor cancers including lung (NSCLC), gastric, esophageal, endometrial
FISH
Ki67 Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cell cycle, while cells in the G0 (quiescent) phase are…
Immunohistochemistry (IHC)
MMR Panel by IHC (MLH1, MSH2, MSH6, PMS2) A well-defined subtype of colorectal cancer (CRC) is characterized by deficiencies in the mismatch repair (MMR) pathway. MMR status may impact prognosis and benefit of adjuvant chemotherapy. MLH1,…
Immunohistochemistry (IHC)
MUC1 Mucin 1 (MUC1) is a high molecular weight glycoprotein that is found on the apical surface of many glandular epithelia, including the gastrointestinal, respiratory, urinary, reproductive tracts and…
Immunohistochemistry (IHC)
Mucicarmine Special stain. Mucicarmine staining is used to identify epithelial mucins, namely acid mucopolysaccharides. Staining is useful to distinguishing mucin negative undifferentiated squamous cell lesions…
Immunohistochemistry (IHC)
PTEN Probes: PTEN (10q23) | GRID1 (10q23.2) | Centromere 10Disease(s): Prostate cancer, melanoma, squamous cell carcinoma of the head and neck (PTEN deletions) This test may be ordered separately or as…
FISH
DNA Ploidy/Cell Cycle Analysis – POC/Solid Tumors Available as a global test only. DNA stain propidium iodide (PI) is used to determine S-phase cell cycle fraction and DNA index as indicators of DNA ploidy. Products of conception (POC) and solid…
Flow Cytometry
MSA Muscle Specific Actin (MSA) antibody recognizes the alpha and gamma isotypes of skeletal, cardiac, and smooth muscle cells. It is non-reactive with other mesenchymal cells and all epithelial cells…
Immunohistochemistry (IHC)
Alcian Blue Special stain. Alcian blue is intended to identify weakly sulfated mucins in tissue samples.
Immunohistochemistry (IHC)
BerEP4 Ber-EP4 recognizes two glycoproteins of 34 and 49 kDa present on the surface and the cytoplasm of all epithelial cells except the superficial layers of squamous epithelial, hepatocytes and parietal…
Immunohistochemistry (IHC)
BG8 This antibody is specific for the Lewis Y (Type 2 Chain) carbohydrate antigen. Lewis Y has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular…
Immunohistochemistry (IHC)
CD31 CD31 is a 130kDa transmembrane glycoprotein that is shared by vascular lining cells, megakaryocytes and platelets. This marker is highly restricted to endothelial neoplasms among all tumors of the…
Immunohistochemistry (IHC)
Pan-Cytokeratin Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin, respectively, thus the combination of these two antibodies can be used to detect almost all human…
Immunohistochemistry (IHC)
CAM 5.2 Anti-Cytokeratin (CAM 5.2) has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 Kd. Cytokeratin 8 is present on secretory epithelia of…
Immunohistochemistry (IHC)
CK HMW (CK903/34BE12) CK903 (34betaE12) is a high molecular weight cytokeratin present in all squamous epithelium and their carcinomas. This antibody recognizes cytokeratins 1, 5, 10 and 14 that are found in complex…
Immunohistochemistry (IHC)
CK20 Cytokeratin 20 (CK20) positivity is seen in the majority of adenocarcinomas of the colon, mucinous ovarian carcinomas, transitional cell, and Merkel cell carcinomas, and frequently in adenocarcinomas…
Immunohistochemistry (IHC)
CK5/6 D5/16 B4 clone of CK5/6 antibody reacts strongly with cytokeratins 5 and 6. Cytokeratin 5/6 have been found valuable for the distinction between low differentiated squamous cell carcinoma and…
Immunohistochemistry (IHC)
CK7 Cytokeratin 7 (CK7) antibody reacts with proteins that are found in most ductal, glandular and transitional epithelium of the urinary tract and bile duct epithelial cells. CK7 distinguishes between…
Immunohistochemistry (IHC)
cMET The cMET tyrosine kinase receptor, normally expressed by epithelial cells, is overexpressed and amplified in a variety of human tumors, including non-small cell lung carcinoma (NSCLC). High levels of…
Immunohistochemistry (IHC)
Vimentin Vimentin is the major intermediate filament in a variety of mesenchymal cells, including endothelial cells, all fibroblastic cells, macrophages, Sertoli cells, melanocytes, lymphocytes and ovarian…
Immunohistochemistry (IHC)
CMV In situ hybridization for detection of cytomegalovirus (CMV) RNA.
In Situ Hybridization (ISH)
NeoTYPE® Discovery Profile for Solid Tumors This profile analyzes 334 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary interpretation of…
Molecular
NeoTYPE® Other Solid Tumor Profile This profile analyzes 29 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide…
Molecular
NeoTYPE® Precision Profile for Solid Tumors This Profile analyzes 51 biomarkers through a combination of next-generation sequencing (NGS) and IHC as listed below. Test orders include summary interpretation of all results to help guide…
Molecular
Comprehensive Hereditary Cancer Panel Next-gen sequencing of all coding regions and intron-exon boundaries is performed concurrently for the following 73 genes: AKT1, APC, ATM, ATR, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4,…
Molecular
EGFR Mutation Analysis Bi-directional sequencing of exons 18-21 of the EGFR gene for detection of EGFR-activating mutations and TKI resistance mutations (including T790M) in these exons. Tumor enrichment is performed…
Molecular
HRAS Mutation Analysis Bi-directional sequencing of HRAS exons 2 and 3 which includes sites of common activating mutations in codons 12, 13, 59 and 61.
Molecular
KRAS Exon 4 Mutation Analysis Bi-directional sequencing of exon 4 of the KRAS gene corresponding to amino acids  R97 through Q150.  Codon 117 and 146 mutations are detected. For solid tumors, tumor enrichment is performed before…
Molecular
KRAS Mutation Analysis Bi-directional sequencing of exons 2 and 3 of the KRAS gene. High-sensitivity sequencing is used for enhanced detection of mutations in codons 12, 13, 59, and 61.  For solid tumors, tumor enrichment…
Molecular
Microsatellite Instability Analysis (MSI) PCR and fragment analysis of paired normal and tumor tissue to determine microsatellite instability (MSI) at the standard five NCI-recommended loci. Positive results are reported as MSI-high (at…
Molecular
NeoARRAY™ SNP/Cytogenetic Profile The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage available, this test employs an enhanced SNP…
Molecular
NeoLAB™ Solid Tumor Monitor - Liquid Biopsy The NeoLAB™ Solid Tumor Monitor is a blood test that uses cell-free circulating tumor DNA (ctDNA) or RNA in combination with next-generation sequencing (NGS) to detect mutations in the following 48…
Molecular
STAT3 Mutation Analysis Bi-directional sequencing of STAT3 exons 13-21 encompassing the DNA binding and SH2 domains.
Molecular
TP53 Mutation Analysis Bi-directional sequencing of TP53 exons 4-9.
Molecular
NKX3.1 NKX3.1 is a protein encoded by the NKX3.1 gene located on chromosome 8. NKX3.1 protein has been found to be positive in the vast majority of primary prostatic adenocarcinomas. NKX3.1 stains nuclei in…
Immunohistochemistry (IHC)
P501S P501S protein, also called the prostein, is a type IIIa plasma membrane protein which is exclusively expressed in cells of normal and malignant prostate. P501S expression has not been detected in…
Immunohistochemistry (IHC)
P504S Expression of P504S protein, or Alpha-methylacyl-CoA Racemase (AMACR), is found in prostatic adenocarcinoma but not in benign prostatic tissue. It has also been found to stain premalignant lesions of…
Immunohistochemistry (IHC)
Prostate Triple Stain The combination of p63 + CK HMW + P504S (PIN-4 cocktail) can be extremely useful for diagnosing prostatic intraepithelial neoplasia (PIN) and/or prostate carcinoma, especially in difficult cases with…
Immunohistochemistry (IHC)
PSA Prostate specific antigen (PSA) is a glycoprotein with a molecular weight of 33-34kDa. It is restricted to the cytoplasm of acinar and ductal epithelia of normal, benign or malignant prostate tissue…
Immunohistochemistry (IHC)
PSAP/HPAP Prostate specific acid phosphatase/human prostatic acid phosphatse (PSAP/HPAP) is a 100kDa glycoprotein present in high concentration in the prostate gland and its secretions. PSAP is specific to the…
Immunohistochemistry (IHC)
PSMA Prostate specific membrane antigen (PSMA) is a 750 amino acid type II membrane glycoprotein with folate hydrolase and neuropeptidase activity. PSMA is expressed in normal and malignant prostatic…
Immunohistochemistry (IHC)
HOXB13 Genotyping This test is performed on a patient's blood specimen to look for germline genetic variants. The method is bi-directional sequencing of exons 1 and 2 of the HOXB13 gene for detection of the G84E…
Molecular
Androgen Receptor Mutation Analysis Bi-directional Sanger sequencing of the gene Androgen Receptor is performed using PCR primers designed to target hotspot mutations in exons 4, 5 and 8.
Molecular
HSD3B1 Genotyping Bi-directional Sanger sequencing is performed to detect the HSD3B1 (1245A>C) single nucleotide polymorphism (SNP). Inheritance of the HSD3B1 (1245C) allele, which enhances dihydrotestosterone…
Molecular
INSM1 INSM1 is a transcription factor that is a sensitive and specific marker for neuroendocrine tumors.  It is a nuclear stain, and is as good if not better than synaptophysin and is superior to…
Immunohistochemistry (IHC)
CancerTYPE ID® with reflex to NeoTYPE® Cancer Profile CancerTYPE ID is a proprietary molecular cancer classifier used to identify unknown or unclear tumor types and subtypes in patients with metastatic cancer. When ordered through NeoGenomics,…
Molecular