Displaying 1 - 55 of 55 tests
AR Androgen receptor (AR) is responsible for the regulation of the growth of the prostate epithelial cells. In untreated prostate carcinoma, AR positive cells are more likely to be responsive to…
Immunohistochemistry (IHC)
BerEP4 Ber-EP4 recognizes two glycoproteins of 34 and 49 kDa present on the surface and the cytoplasm of all epithelial cells except the superficial layers of squamous epithelial, hepatocytes and parietal…
Immunohistochemistry (IHC)
BG8 This antibody is specific for the Lewis Y (Type 2 Chain) carbohydrate antigen. Lewis Y has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular…
Immunohistochemistry (IHC)
CAM 5.2 Anti-Cytokeratin (CAM 5.2) has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 Kd. Cytokeratin 8 is present on secretory epithelia of…
Immunohistochemistry (IHC)
CancerTYPE ID® with reflex to NeoTYPE® Cancer Profile CancerTYPE ID is a proprietary molecular cancer classifier used to identify unknown or unclear tumor types and subtypes in patients with metastatic cancer. When ordered through NeoGenomics,…
Molecular
CD10 CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is expressed in early lymphoid progenitors and normal germinal center cells. It is almost always present on the surface of…
Immunohistochemistry (IHC)
CD31 CD31 is a 130kDa transmembrane glycoprotein that is shared by vascular lining cells, megakaryocytes and platelets. This marker is highly restricted to endothelial neoplasms among all tumors of the…
Immunohistochemistry (IHC)
CD68 CD68 is an antibody directed against lysosomes. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and…
Immunohistochemistry (IHC)
CEA (Mono) Carcinoembryonic antigen (CEA) is usually demonstrated as a linear labeling of the apical poles of cells lining the glandular lumen and occasionally as weak staining near the apex of normal colonic…
Immunohistochemistry (IHC)
CK HMW (CK903/34BE12) CK903 (34betaE12) is a high molecular weight cytokeratin present in all squamous epithelium and their carcinomas. This antibody recognizes cytokeratins 1, 5, 10 and 14 that are found in complex…
Immunohistochemistry (IHC)
CK20 Cytokeratin 20 (CK20) positivity is seen in the majority of adenocarcinomas of the colon, mucinous ovarian carcinomas, transitional cell, and Merkel cell carcinomas, and frequently in adenocarcinomas…
Immunohistochemistry (IHC)
CK5/6 D5/16 B4 clone of CK5/6 antibody reacts strongly with cytokeratins 5 and 6. Cytokeratin 5/6 have been found valuable for the distinction between low differentiated squamous cell carcinoma and…
Immunohistochemistry (IHC)
CK7 Cytokeratin 7 (CK7) antibody reacts with proteins that are found in most ductal, glandular and transitional epithelium of the urinary tract and bile duct epithelial cells. CK7 distinguishes between…
Immunohistochemistry (IHC)
cMET The cMET tyrosine kinase receptor, normally expressed by epithelial cells, is overexpressed and amplified in a variety of human tumors, including non-small cell lung carcinoma (NSCLC). High levels of…
Immunohistochemistry (IHC)
CMV In situ hybridization for detection of cytomegalovirus (CMV) RNA.
In Situ Hybridization (ISH)
COX2 Cyclooxygenase-2 (COX-2) plays a role in tumorigenesis through stimulating epithelial cell proliferation, inhibiting apoptosis, stimulating angiogenesis, enhancing cell invasiveness, mediating immune…
Immunohistochemistry (IHC)
Desmin Desmin is an intermediate filament protein of both smooth and striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well as smooth muscle cells. Anti-desmin antibody is…
Immunohistochemistry (IHC)
DNA Ploidy/Cell Cycle Analysis – POC/Solid Tumors Available as a global test only. DNA stain propidium iodide (PI) is used to determine S-phase cell cycle fraction and DNA index as indicators of DNA ploidy. Products of conception (POC) and solid…
Flow Cytometry
EGFR Mutation Analysis Bi-directional sequencing of exons 18-21 of the EGFR gene for detection of EGFR-activating mutations and TKI resistance mutations (including T790M) in these exons. Tumor enrichment is performed…
Molecular
EMA Epithelial Membrane Antigen (EMA) antibody stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands and squamous epithelium. Hepatocellular carcinoma,…
Immunohistochemistry (IHC)
ER Estrogen Receptor (ER) belongs to a superfamily of nuclear hormone receptors and is expressed in about 85% of invasive breast cancers. There are two known isoforms of estrogen receptor, ERα and ERß.…
Immunohistochemistry (IHC)
X/Y FISH for Molar Pregnancy Probes: Centromere X | Centromere YNote: Testing is performed only on a global basis at this time.Disease(s): Molar pregnancy (hydatidiform mole), partial mole, triploidy
FISH
Ki67 Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cell cycle, while cells in the G0 (quiescent) phase are…
Immunohistochemistry (IHC)
KRAS Exon 4 Mutation Analysis Bi-directional sequencing of exon 4 of the KRAS gene corresponding to amino acids  R97 through Q150.  Codon 117 and 146 mutations are detected. For solid tumors, tumor enrichment is performed before…
Molecular
KRAS Mutation Analysis Bi-directional sequencing of exons 2 and 3 of the KRAS gene. High-sensitivity sequencing is used for enhanced detection of mutations in codons 12, 13, 59, and 61.  For solid tumors, tumor enrichment…
Molecular
MET (c-MET) Mutation Analysis Bi-directional Sanger sequencing of MET is performed using PCR primers designed to target hotspot mutations in exons 14, 16, 17 and 19.
Molecular
MET FISH Probes: MET (7q31) | Centromere 7Disease(s): Multiple solid tumor cancers including lung (NSCLC), gastric, esophageal, endometrial
FISH
Microsatellite Instability Analysis (MSI) PCR and fragment analysis of paired normal and tumor tissue to determine microsatellite instability (MSI) at the standard five NCI-recommended loci. Positive results are reported as MSI-high (at…
Molecular
MLH1 Promoter Methylation Analysis This assay is performed on tumor tissue to detect hypermethylation of the MLH1 gene promoter. Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the…
Molecular
MMR Panel by IHC (MLH1, MSH2, MSH6, PMS2) A well-defined subtype of colorectal cancer (CRC) is characterized by deficiencies in the mismatch repair (MMR) pathway. MMR status may impact prognosis and benefit of adjuvant chemotherapy. MLH1,…
Immunohistochemistry (IHC)
MSA Muscle Specific Actin (MSA) antibody recognizes the alpha and gamma isotypes of skeletal, cardiac, and smooth muscle cells. It is non-reactive with other mesenchymal cells and all epithelial cells…
Immunohistochemistry (IHC)
MUC1 Mucin 1 (MUC1) is a high molecular weight glycoprotein that is found on the apical surface of many glandular epithelia, including the gastrointestinal, respiratory, urinary, reproductive tracts and…
Immunohistochemistry (IHC)
Mucicarmine Special stain. Mucicarmine staining is used to identify epithelial mucins, namely acid mucopolysaccharides. Staining is useful to distinguishing mucin negative undifferentiated squamous cell lesions…
Immunohistochemistry (IHC)
NeoARRAY™ SNP/Cytogenetic Profile The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage available, this test employs an enhanced SNP…
Cytogenetics
NeoARRAY™ SNP/Cytogenetic Profile The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage available, this test employs an enhanced SNP…
Molecular
NeoTYPE® Discovery Profile for Solid Tumors The NeoTYPE Discovery Profile analyzes 336 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all…
Molecular
NeoTYPE® Endometrial Tumor Profile The NeoTYPE Endometrial Tumor Profile analyzes 28 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of…
Molecular
NeoTYPE® Other Solid Tumor Profile The NeoTYPE Other Solid Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of…
Molecular
NeoTYPE® Precision Profile for Solid Tumors The NeoTYPE Precision Profile analyzes 50 biomarkers through a combination of next-generation sequencing (NGS) and IHC as listed below. Test orders include summary interpretation of all results to…
Molecular
NRAS Exon 4 Mutation Analysis Bi-directional sequencing of NRAS exon 4 is performed using PCR primers designed to target hotspot mutations in codons 117 and 146, among other regions in exon 4. Testing is available separately or…
Molecular
NRAS Mutation Analysis Bi-directional sequencing of NRAS exons 2 and 3 which includes sites of common activating mutations in codons 12, 13, 59, and 61. Testing is approved for specimens from the state of New York.
Molecular
p21 p21 is a cyclin dependent protein kinase inhibitor and is a member of a family of proteins that functions to slow down cell division. p21 is found in t cells as they transitions from G1 phase to S…
Immunohistochemistry (IHC)
p27 p27 (KIP1) belongs to the family of cell cycle regulators that cause cell cycle arrest in G1 phase. p27 promotes apoptosis, plays a role in terminal differentiation of some tissues and mediates…
Immunohistochemistry (IHC)
p53 The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results in inactivation of its tumor suppressor function…
Immunohistochemistry (IHC)
Pan-Cytokeratin Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin, respectively, thus the combination of these two antibodies can be used to detect almost all human…
Immunohistochemistry (IHC)
PAX8 The PAX8 gene is a member of the paired box (PAX) family of transcription factors. This family plays critical roles during fetal development and cancer growth. PAX8 is involved in kidney cell…
Immunohistochemistry (IHC)
PgR Progesterone Receptor (PR) belongs to a superfamily of nuclear hormone receptors. Estrogen Receptor (ER) induces PR expression, therefore, PR status serves as an indicator of an intact ER pathway.…
Immunohistochemistry (IHC)
pHistone H3 (PHH3) Phosphohistone H3 (PHH3) is a marker of cells in the late G2-M phase of the cell cycle. It is not expressed in apoptotic cells which may be confused with mitotic figures on a routine H&E stained…
Immunohistochemistry (IHC)
PIK3CA LDT Mutation Analysis by Sequencing Bi-directional sequencing of PIK3CA exons 1, 9, and 20 which are the most commonly-mutated regions of the gene.
Molecular
PMS2 PMS2, also known as PMS1 protein homologue 2, is a DNA mismatch repair (MMR) protein. The PMS2 protein forms a heterodimer with the MLH1 protein which is then activated in the presence of ATP; this…
Immunohistochemistry (IHC)
PTEN Mutation Analysis Bi-directional sequencing of all exons (1-9) of the PTEN gene. For solid tumors, enrichment is performed before extraction. This assay does not detect large deletions.
Molecular
Thrombomodulin (TM) Thrombomodulin (TM) is a plasma membrane-related glycoprotein that has anticoagulant activity. TM antigen is found in several cell types, including megakaryocytes, mesangial cells, synovial cells,…
Immunohistochemistry (IHC)
TP53 Mutation Analysis Bi-directional sequencing of TP53 exons 4-9.
Molecular
Vimentin Vimentin is the major intermediate filament in a variety of mesenchymal cells, including endothelial cells, all fibroblastic cells, macrophages, Sertoli cells, melanocytes, lymphocytes and ovarian…
Immunohistochemistry (IHC)
WT1 Wilms tumor susceptibility gene 1 protein (WT1) has diagnostic utility in the distinction of mesothelioma from adenocarcinoma in tissue sections of pleural tumors. WT1 diffusely stains most ovarian…
Immunohistochemistry (IHC)