Displaying 1 - 50 of 50 tests
ALL FISH Profile (Ph-Like) Probes: PDGFRb (5q32), BCR/ABL1-ASS1 t(9;22), JAK2 (9p24.1), EPOR (19p13.2) and CRLF2 (Xp22.33/Yp11.32) are included in the ALL FISH (Ph-like) Profile. Probes may be ordered separately. Disease(s):…
FISH
ALL Fusion Profile Detection of gene fusion transcripts in Acute Lymphoblastic Leukemia (ALL) from ribonucleic acid (RNA). RNA is isolated from bone marrow aspirates or peripheral blood and the cDNA sequence of…
Molecular
B-Cell Lymphoma Follow-Up Flow Panel Available as global and tech-only. Please provide clinical history including the time after treatment. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly…
Flow Cytometry
B-Cell Gene Rearrangement Detection of clonal IgH gene rearragements by PCR of IgH framework regions 1, 2, 3 and joining regions. In addition, Ig Kappa gene rearrangement analysis is performed using specific oligonucleotides…
Molecular
BCL1/Cyclin D1 BCL1/Cyclin D1 is a nuclear protein detectable in formalin-fixed, paraffin-embedded (FFPE) sections and is found in the majority of mantle cell lymphomas. Hairy cell leukemia and plasmacytoma may…
Immunohistochemistry (IHC)
BCL1 Translocation, t(11;14) Real-time PCR for quantitative detection of t(11;14) BCL1/IgH rearrangements. Analytical sensitivity is approximately 1 tumor cell in 1000 normal cells. Positive results are reported as a ratio…
Molecular
BTK Inhibitor Acquired Resistance Panel Concurrent bi-directional sequencing of hotpost regions in the BTK and PLC-gamma-2 genes. Analysis includes the BTK mutation C481S and surrounding regions corresponding to amino acids C464 to M509…
Molecular
BTK Mutation Analysis Bi-directional sequencing to detect the C481S mutation in exon 15 and other potential mutations within the amino acid range C464 to M509. Testing is available separately or in combination with PLC-…
Molecular
CD10 CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is expressed in early lymphoid progenitors and normal germinal center cells. It is almost always present on the surface of…
Immunohistochemistry (IHC)
CD19 CD19 recognizes a 95kD cell surface glycoprotein which is expressed by cells of the B-cell lineage and follicular dendritic cells. CD19 is a co-receptor of CD21and is an important signal transduction…
Immunohistochemistry (IHC)
CD20 Normal cell expression of CD20 is found on most B-cells (after CD19 and CD10 expression, before CD21/22 expression and surface immunoglobulin expression) and expression is retained on mature B-cells…
Immunohistochemistry (IHC)
CD21 CD21 (CR2, C3d receptor and EBV receptor) is expressed strongly on mature B-cells, follicular dendritic cells (FDC) and weakly on immature thymocytes and T-lymphocytes. In B-cell ontogeny, CD21…
Immunohistochemistry (IHC)
CD22 CD22 expression is restricted to normal and neoplastic B-cells and is absent from other hemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B-cells…
Immunohistochemistry (IHC)
CD23 CD23 is identical to low affinity IgE receptor found on B-cells. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B-lymphoblastoid cell lines. CD23…
Immunohistochemistry (IHC)
CD3 The CD3 antigen is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T-cell lineage. It has a cytoplasmic expression at early…
Immunohistochemistry (IHC)
CD38 CD38 is a transmembrane protein that is highly expressed on thymocytes. It is also present on activated T-cells and terminally differentiated B-cells (plasma cells). Other reactive cells include NK…
Immunohistochemistry (IHC)
CD4 CD4, a single chain transmembrane glycoprotein, is found on a T-cell subset (helper/inducer). It is also present on a variety of monocyte-derived cells, including Langerhans and other dendritic cells…
Immunohistochemistry (IHC)
CD43 CD43 (leukosialin, sialophorin, or leukocyte sialoglycoprotein) is a cell surface glycoprotein that is expressed on all thymocytes, T-cells, and cells of myeloid lineage. CD43 antibody can be useful…
Immunohistochemistry (IHC)
CD5 CD5, a transmembrane protein, is found on most thymocytes and immature peripheral T-cells. It stains normal B-cells of mantle zone of spleen and lymph nodes, B-cells in peritoneal and pleural…
Immunohistochemistry (IHC)
Chromosome Analysis A wide variety of abnormalities can be identified, providing both diagnostic and prognostic information. Acute leukemias, lymphomas and chronic myeloid and lymphoid disorders are examined…
Cytogenetics
CLL FISH Panel Probes: 6q- [SEC63 (6q21), MYB (6q23)] | ATM (11q22.3) | p53 (17p13.1) | Trisomy 12 (Cen 12) | 13q-/-13 (13q14, 13q34) | CCND1/IgH t(11;14) | Probes may be ordered separately (except 12 and 13 are…
FISH
CLL MRD Flow Panel Available as global test only. Markers are CD3, CD5, CD19, CD20, CD22, CD43, CD45, CD79b, and CD81 (9 markers).
Flow Cytometry
CLL/Mantle Cell Companion Add-On Flow Panel Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing.…
Flow Cytometry
Extended Leukemia/Lymphoma Panel - 31 markers Available as global and tech-only. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11b, CD11c, CD13, CD14, CD15, CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD41, CD45, CD56, CD64, CD71, CD117, CD138…
Flow Cytometry
FOXP1 FOX P1 (Forkheadbox-P1) is a transcription factor widely expressed in normal tissues. Its expression is commonly deregulated in malignancies. FOX P1 is differentially expressed in resting and…
Immunohistochemistry (IHC)
IgH Clonality/MRD by NGS The IgH Clonality/MRD by NGS assay detects clonal populations of B-lymphocytes in a given patient sample through the analysis of the VDJ segment of the immunoglobulin heavy chain (IgH) gene. *Note -…
Molecular
IgVH Mutation Analysis RT-PCR and bi-directional sequencing of the variable region of the immunoglobulin heavy chain for detection of mutation from germline sequence. The mutated VH gene family is identified in positive…
Molecular
Ki67 Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cell cycle, while cells in the G0 (quiescent) phase are…
Immunohistochemistry (IHC)
LEF1 LEF1 overexpression is highly associated with CLL/SLL among small B-cell lymphomas and may serve as a useful marker for diagnosis and differential diagnosis of the disease.
Immunohistochemistry (IHC)
Low-Grade/Small B-Cell Lymphoma FISH Panel Probes: BCL6 (3q27) | CCND1/IgH t(11;14) IgH/BCL2 t(14;18) | MALT1 (18q21) Probes may be ordered separately. Disease(s): NHL, B-Cell Lymphoma, MCL, follicular lymphoma, MZL, MALT lymphoma
FISH
MAL MAL is a distinct molecular marker of primary mediastinal large B-cell lymphoma subtype among diffuse large B-cell lymphomas.
Immunohistochemistry (IHC)
NeoARRAY™ SNP/Cytogenetic Profile The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage available, this test employs an enhanced SNP…
Molecular
NeoLAB™ BTK Inhibitor Acquired Resistance Panel - Liquid Biopsy The NeoLAB™ BTK Inhibitor Acquired Resistance Panel is a blood test performed by modified properietary bi-directional sequencing of the BTK and PLC-gamma-2 genes using cell-free circulating tumor DNA…
Molecular
NeoLAB™ Myeloid Disorders Profile - Liquid Biopsy This test is performed on cell-free DNA/RNA in peripheral blood plasma by sequencing the entire coding regions of the genes listed. ABL1, ASXL1, ATRX, BCOR, BCORL1, BRAF, CALR, CBL, CBLB, CBLC,…
Molecular
NeoTYPE® CLL Prognostic Profile This test is performed by sequencing the entire coding regions of the genes ATM, BIRC3, BTK, CARD11, CD79B, CXCR4, MYD88, NOTCH1, SF3B1, TP53, plus IgVH Mutation Analysis and the CLL FISH Panel as…
Molecular
NeoTYPE® MDS/CMML Profile This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. ASXL1, BCOR, BCORL1, BRAF, CBL, CEBPA, CUX1, DNMT3A, ETV6, EZH2, FLT3, HRAS, IDH1,…
Molecular
NOTCH1 Mutation Analysis Bi-directional sequencing of exons 26, 27, and 34 is performed for detection of sequence variant mutations. Testing can be performed on plasma when adequate leukemic cells are not available.
Molecular
PAX5 Paired Box 5 (PAX5) is a B-cell specific activator protein (BSAP). In early stages of B-cell development, PAX5 influences the expression of several B-cell specific genes, such as CD19 and CD20. PAX5…
Immunohistochemistry (IHC)
PLC-Gamma-2 Mutation Analysis Bi-directional sequencing to detect mutations in exons 19, 20, and 24, covering amino acid ranges W646 to S679, A681 to M743, and I839 to V860. Testing is available separately or in combination with…
Molecular
SF3B1 Mutation Analysis RT-PCR and bi-directional sequencing of exons 14-17 of the SF3B1 gene. More than 90% of reported mutations are detected in these exons. This test detects mutations present at 10-15% or more in a wild…
Molecular
SOX11 Nuclear protein expression of SOX-11 is highly associated with both cyclin D1-positive and negative mantle cell lymphoma (MCL). SOX-11 IHC is useful for identifying true cyclin D1-negative MCL and…
Immunohistochemistry (IHC)
Standard Leukemia/Lymphoma Panel - 24 markers Available as global and tech-only. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD13, CD14, CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD45, CD56, CD64, CD117, HLA-DR, kappa, and lambda.
Flow Cytometry
T-Cell Receptor Beta Gene Rearrangement This test provides qualitative detection of monoclonal T-cell receptor (TCR) beta gene rearrangements by PCR and fragment analysis according to BIOMED-2 consensus primer design. This test may be…
Molecular
T-Cell Receptor Gamma Gene Rearrangement Detection of clonal T-cell receptor gamma (TCRG) gene rearrangements by PCR of variable and joining regions. T-Cell Receptor Beta Gene Rearrangement is offered separately and may be added to this…
Molecular
TCL1 T-cell leukemia/lymphoma protein 1 (TCL1) is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of…
Immunohistochemistry (IHC)
T&B Tissue Flow Panel Stand-alone test. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD19, CD20, CD23, CD34, CD38, CD45, CD56, kappa, and lambda (17 markers). 
Flow Cytometry
TP53 Mutation Analysis Bi-directional sequencing of TP53 exons 4-9.
Molecular
Wright Giemsa Cytochemical stain. The Wright Giemsa stain is used to stain peripheral blood and bone marrow smears for study of blood cell morphology.
Immunohistochemistry (IHC)
ZAP70 A prognostic factor in CLL/SLL.
Immunohistochemistry (IHC)
ZAP-70 Lymphoid Panel Available as global and tech-only. Markers are CD3, CD5, CD19, CD45, and ZAP-70.
Flow Cytometry