Alternative Name
RUNX1 Gene Sequencing
Test Description

Bi-directional sequencing of exons 4-10 of the RUNX1 gene

Clinical Significance

RUNX1 mutations are reported in AML, treatment-related MDS, and in blast crisis CML. In AML patients with intermediate-risk cytogenetics, RUNX1 mutations are associated with poor prognosis including shortened overall survival and event-free survival. Germline RUNX1 mutations are known to cause familial platelet disorder with predisposition to AML.

Specimen Requirements

Peripheral blood: 5 mL in EDTA tube. Bone marrow: 2 mL in EDTA tube.

Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen

CPT Code(s)*
Turnaround Time

14 days

Level of Service

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.