Methodology
FISH
Test Description
Probes: ROS1 (6q22.1)
Disease(s): Non-small cell lung carcinoma (NSCLC)
Clinical Significance
ROS1 gene rearrangements are found in 1-2% of non-small cell lung carcinoma (NSCLC). Pre-clinical and early clinical evidence suggests ROS1-rearranged tumors may be sensitive to the dual ALK/MET inhibitor crizotinib.
Specimen Requirements
Paraffin Block: Send paraffin block. Also send circled H&E slide for tech-only (required).
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88377x1 manual or 88374x1 automated.
Turnaround Time
3-5 days
Level of Service
Global
Technical

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.