Methodology
FISH
Test Description
Probes: ROS1 (6q22.1)
Disease(s): Non-small cell lung carcinoma (NSCLC)
Clinical Significance
ROS1 gene rearrangements are found in 1-2% of non-small cell lung carcinoma (NSCLC). Pre-clinical and early clinical evidence suggests ROS1-rearranged tumors may be sensitive to the dual ALK/MET inhibitor crizotinib.
Specimen Requirements
- Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
- Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns. Circle H&E for tech-only.
Storage & Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88377x1 manual or 88374x1 automated.
Turnaround Time
3-5 days
Level of Service
Global
Technical
New York Approved
Yes