Displaying 1 - 13 of 13
The Rapid AML Therapeutic Panel analyzes 13 biomarkers through a combination of bi-directional Sanger sequencing, fragment analysis, and FISH as listed below. Sanger sequencing (6 genes): FLT3 (ITD and TKD), NPM1, CEBPA, IDH1/IDH2, and TP53…
Molecular
Disease(s): APL, AMLProbes: RARA (17q21)
FISH
The RAS/RAF Panel is an NGS-based assay performed by sequencing the entire coding region (full gene) of BRAF, HRAS, KRAS and NRAS genes. The panel reports mutations detected in the full gene including mutations in the most common hotspots, if…
Molecular
Retinoblastoma (RB) is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. RB protein may act by regulating transcription and loss…
Immunohistochemistry (IHC)
In normal kidney, renal cell carcinoma (RCC1, gp200) is localized along the brush border of the proximal tubule. In other normal tissues, RCC is also localized along the luminal surfaces of breast lobules and ducts, the luminal surface of the…
Immunohistochemistry (IHC)
Probes: RET (10q11.2)Disease(s): Lung cancer, thyroid cancer
FISH
Special stain.
Immunohistochemistry (IHC)
Bi-directional sequencing of the gene RHOA. The locked nucleic acid (LNA) technique is used to increase detection sensitivity for the G17V mutation. Note - Available as stand-alone or as part of the NeoTYPE AITL/Peripheral T-Cell Lymphoma Profile.
Molecular
ROS1 gene rearrangements are reported in 1% to 2% of lung adenocarcinomas and are associated with a response to the multi-targeted tyrosine kinase inhibitor crizotinib. ROS1 rearrangement can be detected by using IHC for ROS1 protein as an alternate…
Immunohistochemistry (IHC)
Probes: ROS1 (6q22.1)Disease(s): Non-small cell lung carcinoma (NSCLC)
FISH
RRM1 is crucial for DNA synthesis and damage repair. High levels of RRM1 are associated with G2 cell cycle arrest and increased apoptosis in vitro.
Immunohistochemistry (IHC)
Real-time RT-PCR for quantitative detection of the t(8;21) RUNX1-RUNX1T1 fusion transcript (formerly called AML1-ETO). Analytical sensitivity is 1 tumor cell in 100,000 normal cells. Positive results are reported as a ratio between quantities of (8;…
Molecular
Probes: RUNX1T1/RUNX1 (ETO/AML1) t(8;21)Disease(s): AML-M2
FISH