Methodology
FISH
Test Description
Probes: PTEN (10q23) | Centromere 10
Disease(s): Prostate cancer, melanoma, squamous cell carcinoma of the head and neck, cervix (PTEN deletions)
This test may be ordered separately and is included in the majority of NeoTYPE Solid Tumor Profiles.
Clinical Significance
PTEN is one of the most commonly mutated tumor suppressors in human cancer. Large or complete gene deletions have been reported in prostate cancer, melanoma, and squamous cell carcinoma of the head and neck, CNS, cervix, and at lower frequencies, a variety of other tumors. This FISH test detects large deletions.
Specimen Requirements
- Paraffin Block: Send paraffin block. Also send circled H&E slide for tech-only (required).
- Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
Storage & Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88377x1 manual or 88374x1 automated.
Turnaround Time
3-5 days
Level of Service
Global
Technical
New York Approved
Yes