Probes: PTEN (10q23) | Centromere 10
Disease(s): Prostate cancer, melanoma, squamous cell carcinoma of the head and neck, cervix (PTEN deletions)
This test may be ordered separately and is included in the majority of NeoTYPE Solid Tumor Profiles.
PTEN is one of the most commonly mutated tumor suppressors in human cancer. Large or complete gene deletions have been reported in prostate cancer, melanoma, and squamous cell carcinoma of the head and neck, CNS, cervix, and at lower frequencies, a variety of other tumors. This FISH test detects large deletions.
- Paraffin Block: Send paraffin block. Also send circled H&E slide for tech-only (required).
- Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.