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Alternative Name
Test Description

Probes: Centromere 1 (1p11.1-q11.1) | Centromere 11 (11q12)
Disease(s): Complete molar pregnancy vs. partial mole
This test is available on a global basis only.

Clinical Significance

Ploidy FISH for Molar Pregnancy analyzes copy number of the chromosome 1 centromere and chromosome 11 centromere to assess triploidy (associated with partial molar pregnancy) vs. diploidy (associated with complete molar pregnancy when pathology is consistent).This is an indirect analysis of products of conception (POC) ploidy based on the assumption that trisomy 1 along with trisomy 11 indicates triploidy. An isolated trisomy 1 is extremely rare event and trisomy 11 is an almost negligible incidence; therefore the presence of a combination of the two in the absence of triploidy is expected to be a nearly non-existent event.

An alternative test that can assess ploidy of multiple chromosomes as well as maternal vs. paternal inheritance is the molecular DNA Fingerprinting Analysis. A maternal blood sample is required for DNA Fingerprinting, but not for Ploidy FISH.

Specimen Requirements
  • Bone Marrow Aspirate: N/A
  • Peripheral Blood: N/A  
  • Fresh, Unfixed Tissue: N/A
  • Paraffin Block: H&E slide (required) plus paraffin block. 
  • Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns.
  • Note: Specimen must contain villi and/or fetal tissue.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88377x1 manual or 88374x1 automated
New York Approved
Level of Service
Turnaround Time

5 days

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.