Alternative Name
Platelet-derived growth factor beta
Methodology
FISH
Test Description
Probe(s): PDGFB (22q13.1)
Disease(s): Dermatofibrosarcoma protuberans (DFSP)
Clinical Significance
Dermatofibrosarcoma protuberans (DFSP) commonly has the COL1A1-PDGFB fusion gene and other variants of PDGFB fusion that are related to DFSP pathogenesis and targeted therapies.
Specimen Requirements
- Paraffin Block: Send paraffin block. Also send circled H&E slide for tech-only (required).
- Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
- Bone Marrow Aspirate: N/A
- Peripheral Blood: N/A
- Fresh, Unfixed Tissue: N/A
- Fluids: N/A
Storage & Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88374x1 automated or 88377x1 manual.
Turnaround Time
3-5 Days
Level of Service
Global
Technical
New York Approved
No