This antibody labels the cytoplasm of histiocytes and neoplasms of histiocytic origin, as well as monocytes and macrophages of human colon, tonsil ...
IHC
Alpha-1-Antitrypsin (AAT) is useful in the study of inherited AAT deficiency, benign and malignant hepatic tumors and yolk sac carcinoma. Sensitivity ...
Special stain. Alcian blue is intended to identify weakly sulfated mucins in tissue samples.
Ber-EP4 recognizes two glycoproteins of 34 and 49 kDa present on the surface and the cytoplasm of all epithelial cells except the superficial layers ...
This antibody is specific for the Lewis Y (Type 2 Chain) carbohydrate antigen. Lewis Y has been evaluated as a clinical marker for the diagnosis and p...
In normal tissues, the CA19.9 antigen has been demonstrated in ductal epithelium of the breast, kidney, salivary gland, sweat glands, respiratory epit...
Anti-Cytokeratin (CAM 5.2) has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 Kd. Cytoker...
CD31 is a 130kDa transmembrane glycoprotein that is shared by vascular lining cells, megakaryocytes and platelets. This marker is highly restricted to...
CD68 is an antibody directed against lysosomes. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variet...
CDX2 is an intestine specific transcription factor that regulates both the proliferation and differentiation of intestinal epithelial cells. It is exp...
Carcinoembryonic antigen (CEA) is usually demonstrated as a linear labeling of the apical poles of cells lining the glandular lumen and occasionally a...
Polyclonal carcinoembryonic antigen (CEA) antibody stains a larger percentage of cholangiocarcinomas compared to hepatocellular carcinomas. Approxima...
Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin, respectively, thus the combination of these two antibodie...
CK903 (34betaE12) is a high molecular weight cytokeratin present in all squamous epithelium and their carcinomas. This antibody recognizes cytokeratin...
Cytokeratin 17 (CK17) is an effective marker to distinguish myoepithelial cells from luminal epithelium of various glands (mammary, sweat, salivary, b...
Cytokeratin 19 (CK19) is a member of the type I acidic subfamily of keratins. It is expressed in various different human tissues. CK19 labels ductal ...
Cytokeratin 20 (CK20) positivity is seen in the majority of adenocarcinomas of the colon, mucinous ovarian carcinomas, transitional cell, and Merkel c...
D5/16 B4 clone of CK5/6 antibody reacts strongly with cytokeratins 5 and 6. Cytokeratin 5/6 have been found valuable for the distinction between low d...
Cytokeratin 7 (CK7) antibody reacts with proteins that are found in most ductal, glandular and transitional epithelium of the urinary tract and bile d...
The cMET tyrosine kinase receptor, normally expressed by epithelial cells, is overexpressed and amplified in a variety of human tumors, including non-...
In situ hybridization for detection of cytomegalovirus (CMV) RNA.
ISH
The gene DPC4 (deleted in pancreatic carcinoma 4, also called SMAD4) was identified in 18q21.3 This gene is frequently mutated and deleted in p...
Gastrin, a polypeptide hormone, occurs naturally in three forms: gastrin-14, gastrin-17 and gastrin-34. This antibody labels gastrin or gastrin-analog...
Glucagon antibody is used for the identification of tumors and hyperplasias of pancreatic islets. This antibody labels A cells of the endocrine mammal...
Bi-directional sequencing of exons 8 and 9 of the GNAS gene to detect mutation hot spots in codons R201 and Q227.
Molecular
Next-gen sequencing of all coding regions and intron-exon boundaries is performed concurrently for the following 73 genes: AKT1, APC, ATM, ATR, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CEBPA, CHEK1, CHEK2, CTNNA1, EPCAM, ETV6, FAM175A, GALNT12, GATA2, GEN1, GREM1, HOXB13, KLLN, MEN1, MLH1, MRE11A, MSH2, MSH6, MUTYH, MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH8, MYH9, MYH10, MYH11, MYH13, MYH14, MYH15, NBN, NTRK1, PALB2, PIK3CA, PMS2, POLD1, POLE, PPM1D, PRSS1, PTEN, RAD50, RAD51, RAD51C, RAD51D, RET, RUNX1, SDHB, SDHC, SDHD, SMAD4, STK11, TERC, TERT, TP53, TP53BP1, VHL, WT1, and XRCC2. Note: Patient and physician or genetic counselor signatures on the NeoGenomics Consent for Hereditary Cancer Genetic Testing...
INSM1 is a transcription factor that is a sensitive and specific marker for neuroendocrine tumors. It is a nuclear stain, and is as good if n...
Insulin is composed of a and b chains connected through the C-peptide. The main storage site for insulin is the pancreatic islets. Antibodies to insul...
Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cel...
Bi-directional sequencing of exon 4 of the KRAS gene corresponding to amino acids R97 through Q150. Codon 117 and 146 mutations are det...
Bi-directional sequencing of exons 2 and 3 of the KRAS gene. High-sensitivity sequencing is used for enhanced detection of mutations in codons 12, ...
Mesothelin is a 40kDa cell surface glycoprotein selectively expressed by mesothelial cells and malignant mesotheliomas, as well as by non-mucinous ova...
Bi-directional Sanger sequencing of MET is performed using PCR primers designed to target hotspot mutations in exons 14, 16, 17 and 19.
Probes: MET (7q31) | Centromere 7 Disease(s): Multiple solid tumor cancers including lung (NSCLC), gastric, es...
FISH
Mucin 1 (MUC1) is a high molecular weight glycoprotein that is found on the apical surface of many glandular epithelia, including the gastrointest...
Mucin 2 (MUC2) expression is detected in human tissues such as normal colon, breast, prostate, and salivary gland, as well as in gastrointestinal, col...
Mucin 5 (MUC5) is expressed in gastric mucosa, and in gall bladder epithelium. MUC5 antibody is recommended for use as part of a panel of antibodies f...
Special stain. Mucicarmine staining is used to identify epithelial mucins, namely acid mucopolysaccharides. Staining is useful to distinguishing mucin...
The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverag...
The NeoLAB™ Solid Tumor Monitor is a blood test that uses cell-free circulating tumor DNA (ctDNA) or RNA in combination with next-generation ...
This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. ABL1, ABL2, ACVR1B, AKT1, AKT2, ...
This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. AKT1, BRAF, EGFR, FGFR1, FGFR2, ...
The Pancreas Tumor Profile is an NGS-based assay performed by sequencing the entire coding regions of the genes listed unless other method is noted...
The NeoTYPE Precision Profile for Solid Tumors utilizes next-generation sequencing to detect mutations in the following 48 genes: ABL1, AKT1, ALK, ...
In normal tissue, most neurons and their axonal and dendritic processes stain strongly positive for Neuron Specific Enolase (NSE), with the exception ...
p21 is a cyclin dependent protein kinase inhibitor and is a member of a family of proteins that functions to slow down cell division. p21 is found in ...
p27 (KIP1) belongs to the family of cell cycle regulators that cause cell cycle arrest in G1 phase. p27 promotes apoptosis, plays a role in terminal d...
p40 antibody recognizes δNp63—a p63 isoform. It is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to ...
The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results ...
Phosphohistone H3 (PHH3) is a marker of cells in the late G2-M phase of the cell cycle. It is not expressed in apoptotic cells which may be confused w...
RRM1 is crucial for DNA synthesis and damage repair. High levels of RRM1 are associated with G2 cell cycle arrest and increased apoptosis in vitro....
Expression of S100P, a member of the S100 family, is increased in a number of tumors, including pancreas, lung, breast, and ovary carcinomas. S100P c...
Somatostatin is a useful marker of D-cells of pancreatic islet cells. D-cells are used to identify hyperplasia of the pancreatic islets. Most of these...
Antibody to synaptophysin reacts with neuroendocrine neoplasms of neural as well as epithelial types. In combination with chromogranin A and NSE antib...
Bi-directional sequencing of TP53 exons 4-9.
This antibody labels a mast cell tryptase. It will also show reactivity to basophils, but to a lesser degree.
Tumor Mutation Burden (TMB) testing at NeoGenomics measures the number of non-synonymous DNA coding sequence changes per megabase of sequenced DNA....
The Universal Fusion/Expression Profile is a targeted RNA sequencing panel that utilizes next-generation sequencing (NGS) to detect all relevant fusion transcripts in 1,385 genes associated with hematologic or solid tumor cancers. It is especially useful for testing patients with rare diseases. Learn more about the Universal Fusion/Expression Profile...
Vimentin is the major intermediate filament in a variety of mesenchymal cells, including endothelial cells, all fibroblastic cells, macrophages, Serto...
Special stain. Warthin Starry stain is intended to identify Helicobacter pylori and spirochete microorganisms in tissue samples.