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P120 Catenin is a tyrosine kinase which binds to E-cadherin within the cell membrane. It is detectable in the cell membranes of a wide variety of cells, but predominates in virtually all types of epithelia. When E-cadherin is absent, P120ctn moves…
Immunohistochemistry (IHC)
p16 (p16 -INK4a, p16-MTS1, inhibitor of CDK4) is the product of the CDKN2 gene. It inhibits the progression of the cell cycle through the G1 phase. p16 is a candidate tumor suppressor, whose gene is frequently deleted or mutated in tumors such as…
Immunohistochemistry (IHC)
p21 is a cyclin dependent protein kinase inhibitor and is a member of a family of proteins that functions to slow down cell division. p21 is found in t cells as they transitions from G1 phase to S phase. Low nuclear expression of p21 has been…
Immunohistochemistry (IHC)
p27 (KIP1) belongs to the family of cell cycle regulators that cause cell cycle arrest in G1 phase. p27 promotes apoptosis, plays a role in terminal differentiation of some tissues and mediates chemosensitivity in solid tumors. Decreased p27 KIP1…
Immunohistochemistry (IHC)
p40 antibody recognizes ΔNp63—a p63 isoform. It is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma…
Immunohistochemistry (IHC)
P501S protein, also called the prostein, is a type IIIa plasma membrane protein which is exclusively expressed in cells of normal and malignant prostate. P501S expression has not been detected in other normal or malignant glandular tissues.
Immunohistochemistry (IHC)
Expression of P504S protein, or Alpha-methylacyl-CoA Racemase (AMACR), is found in prostatic adenocarcinoma but not in benign prostatic tissue. It has also been found to stain premalignant lesions of the prostate, high-grade prostatic…
Immunohistochemistry (IHC)
The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results in inactivation of its tumor suppressor function and cellular transformation. Overexpression of…
Immunohistochemistry (IHC)
p57 (Kip 2, CDKN 1C) is an inhibitor of several G1 cyclin complexes and is a negative regulator of cell proliferation. The gene encoding human p57 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and…
Immunohistochemistry (IHC)
p63 is a homologue of the p53 gene and is necessary for normal breast and prostate development. Unlike other markers of myoepithelial cells and basal cells, p63 immunoreactivity is localized to the nucleus of the cells, which can offer distinct…
Immunohistochemistry (IHC)
AKT is a signal transduction protein that plays a central role in inhibiting apoptosis in a variety of tumor types. Constitutive activation of AKT (phosphorylated) has been observed in several human cancers, including lung, breast and prostate. pAKT…
Immunohistochemistry (IHC)
The Pan Melanoma staining combination increases sensitivity for melanomas. Since many skin biopsies are small, the triple stain conserves valuable tissue while saving time. Melan A (brown cytoplasmic) is a useful addition to melanoma panels as it is…
Immunohistochemistry (IHC)
Pan Melanoma/Ki67 serves as a tool to identify the proliferation rate of melanocytic lesions. A high Ki67 rate of a melanocytic lesion raises the possibility of malignancy.
Immunohistochemistry (IHC)
Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin, respectively, thus the combination of these two antibodies can be used to detect almost all human epithelia. In surgical pathology, it is an important…
Immunohistochemistry (IHC)
Pan-TRK (clone EPR17341) is directed against the C-terminal region of TRK (tropomyosin receptor kinase) A, B, and C proteins, which are encoded by NTRK1, NTRK2, and NTRK3 genes respectively.  Pan-TRK IHC staining is a useful screen for…
Immunohistochemistry (IHC)
Complete absence of nuclear staining for parafibromin is diagnostic of parathyroid carcinoma or an HPT-JT-related tumor (hyperparathyroidism-jaw tumor syndrome).
Immunohistochemistry (IHC)
This monoclonal antibody clone, R92F6, recognizes a capsid protein of human parvovirus B19. Therefore, this antibody will be useful in detection of parvovirus infected cells.
Immunohistochemistry (IHC)
Paired Box 2 (PAX2) is a transcription factor that is essential for kidney development. In kidneys of normal adult, Pax2 protein expression is limited to nuclei of collecting ducts and to a lesser extent in distal tubules. PAX2 is expressed in early…
Immunohistochemistry (IHC)
Paired Box 5 (PAX5) is a B-cell specific activator protein (BSAP). In early stages of B-cell development, PAX5 influences the expression of several B-cell specific genes, such as CD19 and CD20. PAX5 is expressed primarily in pro-, pre-, and mature B…
Immunohistochemistry (IHC)
The PAX8 gene is a member of the paired box (PAX) family of transcription factors. This family plays critical roles during fetal development and cancer growth. PAX8 is involved in kidney cell differentiation, and thyroid development. PAX8 has been…
Immunohistochemistry (IHC)
PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded (FFPE) cervical squamous cell carcinoma tissue…
Immunohistochemistry (IHC)
PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded (FFPE) esophageal squamous cell carcinoma (ESCC)…
Immunohistochemistry (IHC)
PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded (FFPE) gastric or gastroesophageal junction…
Immunohistochemistry (IHC)
PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded (FFPE) head and neck squamous cell carcinoma (…
Immunohistochemistry (IHC)
PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in formalin-fixed, paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) tissue…
Immunohistochemistry (IHC)