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Oncology Chromosome Analysis
- Cytogenetics
Cytogenetic analysis can provide an important clinical understanding for diagnosis, prognosis, and available therapies in a wide variety of hematologic tumors. Chromosomal changes can consist of additions and deletions of whole chromosomes or structural changes such as insertions, inversions, translocations, and deletions. In leukemias and lymphomas, chromosomal translocations are identified as a common karyotypic change aiding in disease diagnosis.
Specimen Requirements
BM Aspirate: 1-2 mL sodium heparin tube.
Peripheral Blood: 2-5 mL sodium heparin tube.
CSF: 1-3 mL. All other fluids: 5-10 mL.
Lymph Node and BM Cores (Fresh/Unfixed): One thin cross-section of fresh node with a minimum of 0.3 cm3 tissue. Collect under sterile conditions as if for microbial culture. Place tissue in RPMI and note type of tissue on test requisition. BM Core with a minimum length of 1 cm.
Notes:
- Tissues placed in formalin are unacceptable for cytogenetics.
- Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
- Specimens should be received in our laboratory within 72 hours of collection.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88237, 88264, 88291. Some cases require additional study and may use 88280, 88285 and/or an additional 88237
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: March 09, 2026