In some forms of cancer, especially hematological neoplasms, cytogenetic analysis can determine whether chromosomal changes, either structural or numerical, are present in the malignant cells, thereby facilitating diagnosis, prognosis and treatment options.
- BM Aspirate: 1-2 mL sodium heparin tube.
- Peripheral Blood: 2-5 mL sodium heparin tube.
- Fresh/Unfixed Tissue - Lymph Node or Solid Tumor Tissue Biopsy: One thin cross-section of fresh node or one representative section of solid tumor with minimum 0.5 cm3 tissue. Collect under sterile conditions as if for microbiologic culture. Place tissue in RPMI and note type of tissue on test requisition. Lymph nodes may be sent to our Aliso Viejo, CA or Nashville, TN facility. Send solid tumor samples to the Nashville, TN facility. Please see our contact page for shipping address. Tissues placed in formalin are unacceptable for cytogenetics.
- Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Do not freeze. Use cold pack for transport, make sure cold pack is not in direct contact with specimen.
Bone marrow aspirate/blood: 5 days (standard; 7 days for known or suspected plasma cell neoplasm) | Lymph node/node biopsy: 5 days | Solid tumor: 21 days
- Sandberg AA. Cancer cytogenetics for clinicians. American Cancer Society Journals. https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.3322/canjclin.44.3.136. Published December 31, 2008. Accessed January 11, 2021.