Test by Disease - Non-Hodgkin lymphoma (NHL)

79 Tests in Listing


ALK (2p23) for lymphoma

Probes: ALK (2p23)
Disease(s): Anaplastic large cell lymphoma, NHL

FISH

ALK-1 (for heme cases)

The ALK1 (ALK1 cline) antibody labels normal human ALK protein and the NPM-ALK chimeric protein, and is a useful tool for the identification of the su...

IHC

API2/MALT1 t(11;18)

Probes: API2/MALT1 t(11;18)
Disease(s): MALT lymphoma, NHL

FISH

B-Cell Gene Rearrangement

Detection of clonal IgH gene rearragements by PCR of IgH framework regions 1, 2, 3 and joining regions. In addition, Ig Kappa gene rearrangement analy...

Molecular

B-Cell Lymphoma Follow-Up Flow Panel

Available as global and tech-only. Prior immunophenotyping at NeoGenomics with Standard or Extended Flow Panel is strongly recommended. Clients who...

Flow

BCL1 Translocation, t(11;14)

Real-time PCR for quantitative detection of t(11;14) BCL1/IgH rearrangements. Analytical sensitivity is approximately 1 tumor cell in 1000 normal cell...

Molecular

BCL1/Cyclin D1

BCL1/Cyclin D1 is a nuclear protein detectable in formalin-fixed, paraffin-embedded (FFPE) sections and is found in the majority of mantle cell lympho...

IHC

BCL2

B-cell lymphoma 2 (BCL2) was the first of the translocation-associated proteins to be identified in lymphoma. Most cases of follicular lymphoma have ...

IHC

BCL2

Probes: BCL2 (18q21)
Disease(s): B-cell lymphoma, non-Hodgkin lympoma (NHL), follicular lymphoma (FL), diffuse l...

FISH

BCL2 Translocation, t(14;18)

PCR and fragment analysis for quantitative detection of IGH-BCL2 translocations associated with 70-80% of follicular lymphoma and approximately 20% of...

Molecular

BCL6

BCL6 antibody stains the germinal center cells in lymphoid follicles, the follicular cells and interfollicular cells in follicular lymphoma, a subset ...

IHC

BCL6 (3q27)

Probes: BCL6 (3q27)
Disease(s): Diffuse large B-cell lymphoma, NHL

FISH

CCND1(BCL1)/IgH t(11;14)

Probes: CCND1/IgH t(11;14)
Disease(s): Mantle cell lymphoma, NHL

FISH

CD10

CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is expressed in early lymphoid progenitors and normal germinal center cells. It...

IHC

CD138

CD138 (Syndecan-1) positively stains normal tissue including B-cell precursors and plasma cells. Positive staining in tumors includes myeloma, primary...

IHC

CD15

CD15 (X-Hapten) plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is present on granulocytes, including neutrophils an...

IHC

CD19

CD19 recognizes a 95kD cell surface glycoprotein which is expressed by cells of the B-cell lineage and follicular dendritic cells. CD19 is a co-recep...

IHC

CD2

CD2, the E-rosette receptor, is an extremely broad T-cell marker. This antibody immunostains the vast majority of T-cells and a subset of natural kill...

IHC

CD20

Normal cell expression of CD20 is found on most B-cells (after CD19 and CD10 expression, before CD21/22 expression and surface immunoglobulin express...

IHC

CD21

CD21 (CR2, C3d receptor and EBV receptor) is expressed strongly on mature B-cells, follicular dendritic cells (FDC) and weakly on immature thymocytes ...

IHC

CD22

CD22 expression is restricted to normal and neoplastic B-cells and is absent from other hemopoietic cell types. In B-cell ontogeny, CD22 is first expr...

IHC

CD23

CD23 is identical to low affinity IgE receptor found on B-cells. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on ...

IHC

CD25

The interleukin-2 receptor is designated CD25. Originally isolated from T-lymphocytes, it is now known to be expressed on hairy cell leukemia and adu...

IHC

CD3

The CD3 antigen is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T-cell l...

IHC

CD30

CD30 is a lymphocyte activation antigen, related to tumor necrosis factor. It is expressed in activated B-, T- and NK cells. Positive staining is seen...

IHC

CD34

CD34, a single chain transmembrane glycoprotein, is selectively expressed on human lymphoid and myeloid hematopoietic progenitor cells and endothelial...

IHC

CD43

CD43 (leukosialin, sialophorin, or leukocyte sialoglycoprotein) is a cell surface glycoprotein that is expressed on all thymocytes, T-cells, and cells...

IHC

CD45 (LCA)

CD45 (Leukocyte Common Antigen, LCA) is comprised of at least four isoforms (CD45RA, CD45RB, CD45RC and CD45RO) of membrane glycoproteins. CD45 is exp...

IHC

CD45RO

CD45RO (an isoform of leukocyte common antigen) reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within ...

IHC

CD5

CD5, a transmembrane protein, is found on most thymocytes and immature peripheral T-cells. It stains normal B-cells of mantle zone of spleen and lymph...

IHC

CD56

CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally-derived cell lines, tissues ...

IHC

CD57

CD57 is expressed on subpopulations of peripheral blood mononuclear cells, NK active cells and T-cells. Hematopoietic malignancies that are CD57+ incl...

IHC

CD7

CD7 is expressed on the majority of immature and mature T-lymphocytes and T-cell leukemia. It is also found on natural killer cells, and a small subpo...

IHC

CD79a

CD79a first appears at the pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found ...

IHC

CD79B Mutation Analysis

Bi-directional sequencing of exon 5 of the CD79B gene which includes detection of the common Y196 mutations. Testing is available separately or as par...

Molecular

CD8

CD8 is a T-cell marker for the detection of cytotoxic/suppressor T-cells. CD8 is also detected on NK cells, most thymocytes, a subpopulation of null c...

IHC

Chromosome Analysis

A wide variety of abnormalities can be identified, providing both diagnostic and prognostic information. Acute leukemias, lymphomas and chronic mye...

Cytogenetics

cMyc

cMyc protein is a transcription factor localized to the nucleus of the cell. Amplification of the cMyc gene has been found in several types of human ...

IHC

EBER

This probe set labels all latent EBV-infected cells, including EBV-positive lymphoblastoid cell lines and EBV infected B-cell immunoblasts in infectio...

ISH

EBV (LMP1)

This antibody reacts strongly with Epstein Barr Virus (EBV)-positive lymphoblastoid cell lines and EBV infected B-cell immunoblasts in infectious mono...

IHC

EMA

Epithelial Membrane Antigen (EMA) antibody stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands and squ...

IHC

EZH2 Mutation Analysis

Bi-directional sequencing of exons 3-13 and 15-18 of the EZH2 gene.

Molecular

FOXP1

FOX P1 (Forkheadbox-P1) is a transcription factor widely expressed in normal tissues. Its expression is commonly deregulated in malignancies. FOX P1 ...

IHC

GCET1

The GCET1 gene codes for a serpin expressed in germinal center (GC) B-cells. GCET1 is highly restricted to a subset of GC B-cells and GC-derive...

IHC

HGAL

HGAL is specifically expressed in the cytoplasm of germinal center B-cells, but is absent in mantle and marginal zone. This antibody is highly specif...

IHC

High-Grade/Large B-Cell Lymphoma Panel (NY and non-NY)

Probes: BCL6 (3q27) | MYC (8q24) | IgH/BCL2 t(14;18) | Optional probes: MYC/IgH/CEN8 t(8;14) [available to all clients] and BCL2 (...

FISH

IgD

IgD antibody reacts with immunoglobulin Ig delta chains. This antibody is useful when identifying leukemias, plasmacytomas and B-cell lineage lymphoma...

IHC

IgG

IgG antibody reacts with immunoglobulin Ig gamma chains. This antibody may be useful in identifying plasma cytomas and B-cell lineage lymphomas, and ...

IHC

IgH (14q32)

Probes: IgH (14q32)
Disease(s): Lymphoma, NHL, multiple myeloma, MGUS

FISH

IgH Clonality/MRD by NGS

The IgH Clonality/MRD by NGS assay detects clonal populations of B-lymphocytes in a given patient sample through the analysis of the VDJ segment of...

Molecular

IgH/BCL2 t(14;18)

Probes: IgH/BCL2 t(14;18)
Disease(s): Follicular lymphoma, NHL

FISH

IgM

IgM antibody reacts with immunoglobulin Ig mu chains. This antibody is useful when identifying leukemias, plasmacytomas and B-cell lineage...

IHC

Kappa

Antibody to the kappa light chain of immunoglobulin is reportedly useful in the identification of leukemias, plasmacytomas and certain non-Hodgkin lym...

IHC

Kappa

Each test contains a set of oligonucleotide probes. The intended target is the kappa light chain immunoglobulin messenger RNA (mRNA) in the cytoplasm ...

ISH

Ki67

Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cell ...

IHC

Ki67/Caspase 3 (Double Stain)

The Ki67/caspase-3 antibody cocktail was designed to provide information on apoptosis versus cell proliferation rates. The Ki67 is associated with cel...

IHC

Lambda

Each test contains a set of oligonucleotide probes. The intended target is the lambda light chain immunoglobulin messenger RNA (mRNA) in the cytopl...

ISH

Low-Grade/Small B-Cell Lymphoma FISH Panel

Probes: BCL6 (3q27) | CCND1/IgH t(11;14) IgH/BCL2 t(14;18) | MALT1 (18q21)
Probes may be ordered separately.
D...

FISH

MALT1 (18q21)

Probes: MALT1 (18q21)
Disease(s): Marginal zone B-cell lymphoma, NHL

FISH

MUM1

The MUM1 antibody is specific for the MUM1/IRF4 protein that is overexpressed in late plasma-cell-directed stages of B-cell differentiation. MUM1 is a...

IHC

MYC (8q24)

Probes: MYC (8q24)
Disease(s): Lymphoma, NHL, B-ALL

FISH

MYC/IgH/Cen 8 t(8;14)

Probes: Trisomy 8 (Cen 8) | MYC/IgH t(8;14)
Disease(s): Burkitt lymphoma, NHL

FISH

MYD88 Mutation Analysis

Bi-directional sequencing of exon 5 of the MYD88 gene which includes detection of the common L265P mutation.

Molecular

NeoARRAY™ SNP/Cytogenetic Profile

The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage a...

Molecular

NeoARRAY™ SNP/Cytogenetic Profile

The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage a...

Cytogenetics

NeoTYPE AITL/Peripheral T-Cell Lymphoma Profile

The NeoTYPE AITL/Peripheral T-Cell Lymphoma Profile is performed by the sequencing of select exons in the genes IDH1, IDH2, DNMT3A, TET2 and RHOA...

Molecular

NeoTYPE Cancer Exome Profile

The NeoTYPE™ Cancer Exome Profile is performed by massive parallel sequencing of the coding regions in 4813 different cancer related genes. T...

Molecular

NeoTYPE Lymphoma Profile

This test is performed by the sequencing of select exons of the genes listed. BCL1, BCL2, BRAF, CARD11, CD79B, EZH2, MYD88 and NRAS. Test orders in...

Molecular

Non-Hodgkin's Lymphoma (NHL) FISH Panel

Probes: ALK (2p23) | BCL6 (3q27) | MYC (8q24) | CCND1/IgH t(11;14) | IgH (14q32) | IgH/BCL2 t(14;18) | MALT1 (18q21)
Probes ma...

FISH

PAX5

Paired Box 5 (PAX5) is a B-cell specific activator protein (BSAP). In early stages of B-cell development, PAX5 influences the expression of several B-...

IHC

PD1

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and sugg...

IHC

Standard Leukemia/Lymphoma Panel - 24 markers

Available as global and tech-only. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD13, CD14, CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD4...

Flow

T&B Tissue Flow Panel

Stand-alone test. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD19, CD20, CD23, CD34, CD38, CD45, CD56, kappa, and lambda (17 markers).&...

Flow

T-Cell Receptor Beta Gene Rearrangement

This test provides qualitative detection of monoclonal T-cell receptor (TCR) beta gene rearrangements by PCR and fragment analysis according to BIOMED-2 consensus primer design. This test may be ordered concurrently with or after negative results in our T-Cell Receptor Gamma Gene Rearrangement...

Molecular

T-Cell Receptor Gamma Gene Rearrangement

Detection of clonal T-cell receptor gamma (TCRG) gene rearrangements by PCR of variable and joining regions. T-Cell Receptor Beta Gene Rearrangemen...

Molecular

TP53 Mutation Analysis

Bi-directional sequencing of TP53 exons 4-9.

Molecular

Universal Fusion/Expression Profile

The Universal Fusion/Expression Profile is a targeted RNA sequencing panel that utilizes next-generation sequencing (NGS) to detect all relevant fusion transcripts in 1,385 genes associated with hematologic or solid tumor cancers. It is especially useful for testing patients with rare diseases. Learn more about the Universal Fusion/Expression Profile...

Molecular

V-Beta T-Cell Clonality

Available as global test only. Markers are VB1, VB2, VB3, VB4, VB5.1, VB5.2, VB5.3, VB7.1, VB7.2, VB8, VB9, VB11, VB12, VB13.1, VB13.2, VB13.6, VB1...

Flow

Wright Giemsa

Special stain. The Wright Giemsa stain is used to stain peripheral blood and bone marrow smears for study of blood cell morphology.

IHC

 

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