The NGS Thyroid Profile for non-Medullary Thyroid Cancer (non-MTC) analyzes 26 genes using next-generation sequencing (NGS) and FISH as listed below. Test orders include summary interpretation of all results to help guide treatment decisions.
NGS: AKT1, ALK, ARID1A, ATM, BRAF, CDKN2A, CTNNB1, ERBB2, ERBB4, HRAS, KRAS, MEN1, MET, NF1, NF2, NRAS, PIK3CA, PTEN, RET, SMAD4, SMO, SRC, TERT Promoter, TP53, TSC1, and TSC2
This test is available through the Lilly-sponsored Thyroid Cancer Testing Program only. A separate test request form is required. Please visit Thyroid Cancer Testing Program for more information and to download the Test Request Form.
The NGS Thyroid Profile for non-MTC is useful to classify fine needle aspirates of thyroid nodules that are indeterminate or suspicious on cytology. Presence of mutations or gene rearrangements as detected by FISH predicts malignancy with varying degrees of specificity depending on the gene mutated and histological subtype. BRAF mutation V600E is associated with poor prognosis in papillary thyroid carcinoma (PTC).
- FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.