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Methodology
Molecular
Test Description

The NGS Thyroid Profile for Medullary Thyroid Cancer (MTC) analyzes 26 genes using next-generation sequencing (NGS) as listed below. Test orders include summary interpretation of all results to help guide treatment decisions.

  • NGS: AKT1, ALK, ARID1A, ATM, BRAF, CDKN2A, CTNNB1, ERBB2, ERBB4, HRAS, KRAS, MEN1, MET, NF1, NF2, NRAS, PIK3CA, PTEN, RET, SMAD4, SMO, SRC, TERT Promoter, TP53, TSC1, and TSC2

This test is available through the Lilly-sponsored Thyroid Cancer Testing Program only. A separate test request form is required. Please visit Thyroid Cancer Testing Program for more information and to download the Test Request Form.

Clinical Significance

The NGS Thyroid Profile for MTC is useful to identify genetic mutations associated with medullary thyroid cancer, such as RET alterations, which can determine which patients are eligible for currently available targeted therapies.

Specimen Requirements
  • FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

14 Days

Level of Service
Global

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.