The NGS Thyroid Profile for Medullary Thyroid Cancer (MTC) analyzes 26 genes using next-generation sequencing (NGS) as listed below. Test orders include summary interpretation of all results to help guide treatment decisions.
- NGS: AKT1, ALK, ARID1A, ATM, BRAF, CDKN2A, CTNNB1, ERBB2, ERBB4, HRAS, KRAS, MEN1, MET, NF1, NF2, NRAS, PIK3CA, PTEN, RET, SMAD4, SMO, SRC, TERT Promoter, TP53, TSC1, and TSC2
This test is available through the Lilly-sponsored Thyroid Cancer Testing Program only. A separate test request form is required. Please visit Thyroid Cancer Testing Program for more information and to download the Test Request Form.
The NGS Thyroid Profile for MTC is useful to identify point mutations and small insertion/deletion mutations associated with medullary thyroid cancer which can determine which patients are eligible for currently available targeted therapies.
- FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.