There are several key genes recurrently mutated in lung cancer. Genomic DNA is isolated from formalin fixed paraffin embedded tissue and the DNA sequence of targeted regions of the ALK, BRAF, CD274, EGFR, ERBB2, KRAS (includes G12C mutation), and MET genes is determined using next-generation sequencing (NGS) technology.
The Lung Targeted Profile can be ordered concurrently with:
- FISH: ALK, ROS1, RET
- IHC: PD-L1 22C3
For predictive and prognostic purposes.
- Tissue (Preferred): Two (2) formalin-fixed, paraffin-embedded tissue/ fine needle aspirate (FFPE/FNA) blocks containing tumor tissue from recent surgery or biopsy or sixteen (16) 2x5 µm sections with accompanying H&E slide.
- Acceptable Alternative: One (1) formalin-fixed, paraffin-embedded tissue/fine needle aspirate (FFPE/FNA) block containing tumor tissue from recent surgery or biopsy or eight (8) 2×5 µm sections with accompanying H&E slide.
- Unacceptable: Specimens preserved in alternative (non-formalin) fixatives, decalcified specimens, fresh or frozen tissue.
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. DO NOT FREEZE.
12 Days