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NeoTYPE® HRR Profile
- Next Generation Sequencing (NGS)
The NeoTYPE HRR Profile analyzes 31 biomarkers through a combination of next-generation sequencing (NGS) and IHC as listed below. NGS (30 genes): ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, MLH1, MRE11A, MSH2, MSH6, NBN, PALB2, PMS2, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD54L, TP53 IHC (1 biomarker): PD-L1 LDT (tech-only available for PD-L1).
Specimen Requirements
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Storage and Transportation
Storage & Transportation: Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81445x1; 88360x1
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
DNA Sequencing
| SNVs + Indels | |||||
|---|---|---|---|---|---|
| BRCA2 | BRIP1 | PALB2 | RAD51C | ATM | ATR |
| BARD1 | BRCA1 | CDK12 | CHEK1 | CHEK2 | FANCA |
| FANCC | FANCD2 | FANCE | FANCF | FANCG | FANCL |
| MLH1 | MRE11 | MSH2 | MSH6 | NBN | PMS2 |
| RAD50 | RAD51 | RAD51B | RAD51D | RAD54L | TP53 |
Immunohistochemistry (IHC)
| Expression | |||||
|---|---|---|---|---|---|
| PD-L1 | |||||
Last Updated: December 06, 2025