Homologous recombination repair (HRR) is a DNA repair pathway involved in the repair of double‑stranded DNA breaks. The NeoTYPE HRR Profile evaluates HRR‑related biomarkers using next‑generation sequencing (NGS) and immunohistochemistry (IHC).
NGS – SNVs / Indels (30 genes)
IHC (1 biomarker)
* PD‑L1
* PD‑L1 LDT (tech‑only available)
NeoTYPE® HRR Profile
- Next Generation Sequencing (NGS)
Specimen Requirements
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81445x1; 88360x1
Turnaround time
14 Days
NGS: 14 Days
IHC: Global: 2 Days
Tech-Only: 24 Hours
Level of Service
- Global
Integrations
Request electronic integrations →
New York Approved: Yes
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
DNA Sequencing
| SNVs + Indels | |||||
|---|---|---|---|---|---|
| ATM | ATR | BARD1 | BRCA1 | BRCA2 | BRIP1 |
| CDK12 | CHEK1 | CHEK2 | FANCA | FANCC | FANCD2 |
| FANCE | FANCF | FANCG | FANCL | MLH1 | MRE11 |
| MSH2 | MSH6 | NBN | PALB2 | PMS2 | RAD50 |
| RAD51 | RAD51B | RAD51C | RAD51D | RAD54L | TP53 |
Immunohistochemistry (IHC)
| Expression | |||||
|---|---|---|---|---|---|
| PD-L1 | |||||
Last Updated: April 29, 2026