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Alternative Name
Angioimmunoblastic/Peripheral T-Cell Lymphoma Profile
Methodology
Molecular
Test Description

The NeoTYPE AITL/Peripheral T-Cell Lymphoma Profile is performed by the sequencing of all exons in the genes BCL1 (CCND1), IDH1, IDH2, DNMT3A, TET2 and select exons in RHOA.

Clinical Significance

Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma (PTCL) and accounts for 20-25% of PTCLs. Peripheral T-cell lymphoma is known as an aggressive group of lymphoid malignancies and represent about 10-15% of non-Hodgkin lymphomas. Frequent mutations have been detected in the genes IDH1/2, DNMT3A, TET2 and RHOA in patients diagnosed with AITL. These mutations may play a role in the pathogenesis of AITL/PTCLs. 

Specimen Requirements
  • Bone marrow (Preferred): 2 mL in EDTA tube.
  • Peripheral blood: 5 mL in EDTA tube.
  • FFPE tissue: Paraffin block. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative is the recommended fixative. Do not use zinc or mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible; specimens <72 hours old preferred.

CPT Code(s)*
81479x1
Turnaround Time

14-21 days

Level of Service
Global

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.