This test is performed by sequencing of select exons of the genes listed unless another method is noted: BRAF, HRAS, KRAS, Microsatellite Instability Analysis (MSI), NRAS, HER2 FISH, PD-L1 IHC. MSI is performed by fragment analysis. Tumor Mutation Burden (TMB) testing and individual genes from a validated list of genes can be added. Test orders include summary interpretation of all results together. FISH components of NeoTYPE Profiles may be ordered as "Tech-Only" by pathology clients who wish to perform the professional component.
The NeoTYPE GI Predictive Profile characterizes GI tumors of any histological subtype for the most significant genetic changes relevant to therapy decisions, prognosis, and clinical research. It is especially relevant to colorectal or gastroesophageal tumors. It is appropriate for patients with new-diagnosed or recurrent disease, and for patients with resistant disease to explore options in clinical trials.
Specimen requirements for normal tissue in order of preference are:
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. All slides can be packed at room temperature.
81210X1, 81403X2, 81275X1, 81276X2, 81311X1, 81301X1, 88374x1, 88360x1, G0452X1, add 81479x1 if Tumor Mutation Burden is ordered.