The NeoLAB™ Solid Tumor Monitor is a blood test that uses cell-free circulating tumor DNA (ctDNA) or RNA in combination with next-generation sequencing (NGS) to detect mutations in the following 48 genes: ABL1, AKT1, ALK, APC, ATM, BRAF, CDH1, CDKN2A, CSF1R, CTNNB1, EGFR, ERBB2, ERBB4, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, JAK2, JAK3, KDR, KIT, KRAS, MET, MLH1, MPL, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PTEN, PTPN11, RB1, RET, SMAD4, SMARCB1, SMO, SRC, STK11, TP53, and VHL. The EGFR T790 mutation is tested at high sensitivity (10^-4). Test orders include summary interpretation of all results together. NOTE: One-time baseline molecular testing at NeoGenomics on the solid tumor is required. Please see details in Specimen Requirements.
Molecular profiling with the NeoLAB Solid Tumor Monitor assay is useful for monitoring response to therapy, monitoring heterogeneity, and predicting early relapse. Testing can also provide information to develop strategies for the treatment and management of the underlying disease. This test can also be used in current or future clinical research projects.
This test is available to patients who have metastatic disease at the time of blood draw and have satisfied NeoGenomics one-time solid tumor testing requirements listed below.
- Peripheral blood: 2 x 6 mL EDTA tubes (total 12 mL) or 10 mL in EDTA tube.
- One-time solid tumor testing requirements (one condition must apply): --Patient’s tumor has previously tested positive for mutation(s) with one of the solid tumor tests at NeoGenomics OR --NeoTYPE™ Precision Profile is run concurrently with the blood sample for monitoring if prior solid tumor testing not performed. Please note that in all cases, tumors tested outside of NeoGenomics will need to be retested by the NeoTYPE Precision Profile for Solid Tumors in order establish a baseline tumor mutation profile and follow clonal evolution via the blood sample.
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible; specimens <72 hours old preferred.