Neo Comprehensive - Myeloid Disorders

Next Generation Sequencing (NGS)

The Neo Comprehensive – Myeloid Disorders assay analyzes 164 genes to detect DNA and RNA alterations by next‑generation sequencing (NGS) for diagnostic evaluation, prognosis, risk stratification, and therapy guidance in myeloid neoplasms. Test reports include summary interpretation of all results to help guide treatment decisions.

Note:
FLT3 by PCR (via FLT3 Mutation Analysis) is available as Client‑Bill only when ordered concurrently with the Neo Comprehensive Myeloid Disorders assay. This result is reported separately from the Neo Comprehensive profile to support prompt therapy selection for patients with a new diagnosis of AML.

Turnaround time

14 Days

Level of Service

Global

New York Approved: Yes

Clinical Significance

The Neo Comprehensive - Myeloid Disorders assay detects relevant aberrations for the purpose of diagnostic evaluation, prognosis, risk stratification, and therapy guidance. It covers a wide spectrum of myeloid neoplasms, including acute myeloid leukemia (AML); chronic myeloid leukemia (CML); chronic myelomonocytic leukemia (CMML); myelodysplastic neoplasms (MDS); myeloproliferative neoplasms (MPN), e.g., polycythemia vera (PV), primary myelofibrosis (PMF), and essential thrombocythemia (ET); myeloid neoplasms with eosinophilia and defining gene rearrangement; histiocytic neoplasms, such as Langerhans cell histiocytosis (LCH) or Erdheim-Chester Disease (ECD); mastocytosis; myeloid precursor lesions.

Specimen Requirements

Bone Marrow Aspirate: 2-3 mL in EDTA tube. Sodium heparin is acceptable.
Peripheral Blood: 3-5 mL in EDTA tube. Sodium heparin is acceptable.
H&E slide: Required, plus paraffin block.
Cut Slides: H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Do not use: Mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note on fresh samples: NeoGenomics should receive within 7 days from collection for acceptable cell viability.
Note: Test is TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.

Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. NYS clients please provide date and time of collection. Please select Extract & Hold - TNA if specimen hold service is desired.

CPT Code(s)*

81455

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Biomarkers

DNA Sequencing

SNVs + Indels
ABL1	ANKRD26	APC	ARAF	ASXL1	ATM
ATRX	BCOR	BCORL1	BLM	BRAF	BRCA1
BRCA2	BRIP1	CALR	CBL	CBLB	CBLC
CDKN2A	CEBPA	CHEK2	CSF3R	CTC1	CUX1
CXCR4	DDX41	DKC1	DNMT3A	ELANE	EPCAM
ERCC4	ETNK1	ETV6	EZH2	FANCA	FANCB
FANCC	FANCD2	FANCE	FANCF	FANCG	FANCI
FANCL	FANCM	FBXW7	FLT3	G6PC3	GATA1
GATA2	GFI1	GNAS	GNB1	HAX1	HRAS
IDH1	IDH2	IKZF1	IKZF3	ITPKB	JAK2
JAK3	KDM6A	KIT	KMT2A	KRAS	MAP2K1
MET	MLH1	MPL	MSH2	MSH6	MYD88
NF1	NHP2	NOP10	NOTCH1	NPM1	NRAS
PALB2	PDGFRA	PHF6	PIGA	PML	PMS2
PPM1D	PRPF8	PTEN	PTPN11	RAD21	RAD51C
RB1	RPL11	RPL35A	RPL5	RPS10	RPS17
RPS26	RPS7	RTEL1	RUNX1	SAMD9	SAMD9L
SBDS	SETBP1	SETD2	SF3B1	SH2B3	SLX4
SMC1A	SMC3	SRP72	SRSF2	STAG2	STAT3
STAT5B	SUZ12	TERC	TERT	TET2	TINF2
TP53	U2AF1	VHL	WAS	WRAP53	WT1
ZRSR2

CNVs
ABL1	ASXL1	ATG2B	BRAF	CDKN1B	CDKN2A
DNMT1	ETV6	EZH2	GSKIP	JAK2	KMT2A
KRAS	MYC	RAD21	TP53

RNA Sequencing

Fusions
ABL1	AFDN	AFF1	ALK	BCL11B	CBFB
CEP43	CPSF6	CREBBP	DEK	ELL	EP300
ETV6	FGFR1	FLT3	GLIS2	JAK2	KMT2A
MECOM	MLLT1	MLLT3	MRTFA	MYB	MYH11
NTRK3	NUP214	NUP98	PCM1	PDGFRA	PDGFRB
PICALM	PML	PRDM16	RARA	RBM15	RPN1
RUNX1	RUNX1T1	TCF3	ZNF384

Fluorescence In Situ Hybridization (FISH)

CNVs
CBFB

Last Updated: March 02, 2026

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.