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Alternative Name
c-MYC Amplification
Test Description

Probes: MYC (8q24) | Centromere 8
Disease(s): Angiosarcoma

Clinical Significance

MYC gene dysregulation is frequently observed across various cancer types. In angiosarcoma, assessing MYC [c-MYC] amplification status provides diagnostic and prognostic information to distinguish post-radiation angiosarcoma from other angiosarcomas and non-neoplastic vascular proliferations.

Specimen Requirements
  • Paraffin Block: Send paraffin block. Also send circled H&E slide for tech-only (required).
  • Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
  • Bone Marrow Aspirate: N/A
  • Peripheral Blood: N/A
  • Fresh, Unfixed Tissue: N/A
  • Fluids: N/A
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88374x1 automated or 88377x1 manual.
New York Approved
Level of Service
Turnaround Time

3-5 Days

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.