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Alternative Name
Myeloprofilerative neoplasms
Test Description

Probes: PDGFRa, CHIC2, FIP1L1 (4q12) | PDGFRb (5q33) | FGFR1 (8p11) | BCR/ABL1 t(9;22) including ASS1 (9q34) | Probes may be ordered separately.
Disease(s): Myeloproliferative neoplasms

Clinical Significance

The MPN FISH panel is indicated in the diagnosis of myeloproliferative neoplasms with eosinophilia and as a guide to therapeutic selection. Patients with BCR-ABL, PDGFRA or PDGFRB rearrangements are responsive to tyrosine kinase inhibitors. There currently is no established TKI therapy for diseases with FGFR1 rearrangement, but some promising new therapies have been reported. If these FISH studies are negative, that does not exclude a myeloproliferative neoplasm and molecular studies for JAK2 and/or MPL mutations should also be considered in the work-up of a possible myeloproliferative neoplasm.

Specimen Requirements
  • Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
  • Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
  • Fresh, Unfixed Tissue: Tissue in RPMI.
  • Fluids: Equal parts RPMI to specimen volume.
  • Paraffin Block or Cut Slides: Not available.
  • Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88374x4 automated. Codes may differ if manual analysis is performed.
New York Approved
Level of Service
Turnaround Time

3-5 days

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.