Detects the MLL partial tandem duplication (PTD) between exons 2 and 8 in the MLL gene by polymerase chain reaction (PCR).
MLL partial tandem duplication (PTD) is found in approximately 5-11% of cytogenetically normal acute myeloid leukemia (AML) and up to 90% of AML with trisomy 11. In patients with AML, MLL-PTD is an adverse prognostic indicator for overall survival.1-2
- Bone Marrow (Preferred): 2-3 mL in EDTA tube
- Peripheral Blood: 2-3 mL in EDTA tube
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. DO NOT FREEZE.
- Dohner H, et al. Acute myeloid leukemia. N Engl J Med 2015;373:1136-52.
- Patel J, et al. Prognostic relevance of integrated genetic in acute myeloid leukemia. N Engl J Med 2012;366:1079-89.