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Test Description

Detects the MLL partial tandem duplication (PTD) between exons 2 and 8 in the MLL gene by polymerase chain reaction (PCR).

Clinical Significance

MLL partial tandem duplication (PTD) is found in approximately 5-11% of cytogenetically normal acute myeloid leukemia (AML) and up to 90% of AML with trisomy 11. In patients with AML, MLL-PTD is an adverse prognostic indicator for overall survival.1-2

Specimen Requirements
  • Bone Marrow (Preferred): 2-3 mL in EDTA tube
  • Peripheral Blood: 2-3 mL in EDTA tube
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. DO NOT FREEZE.

CPT Code(s)*
New York Approved
Level of Service
Turnaround Time

8 Days

  1. Dohner H, et al. Acute myeloid leukemia. N Engl J Med 2015;373:1136-52.
  2. Patel J, et al. Prognostic relevance of integrated genetic in acute myeloid leukemia. N Engl J Med 2012;366:1079-89.

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.