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Alternative Name
E3 ubiquitin ligase
Test Description

Probes: MDM2 (12q15) | Centromere 12
Disease(s): Liposarcoma

Clinical Significance

This test detects amplifications of the MDM2 gene for classification of certain adipocytic tumors. MDM2 gene amplifications may appear microscopically as ring chromosomes, giant marker chromosomes, and double minutes. MDM2 amplifications are frequently detected in well-differentiated liposarcoma, which includes atypical lipomatous tumor (ALT/WDLS), and in dedifferentiated liposarcoma (DDLS). These tumors can be difficult to distinguish morphologically from other high-grade sarcomas and benign tumors. Amplifications are detected infrequently in other soft tissue sarcomas, and are not detected in benign lipomas. Drug targeting of MDM2 is an active area of clinical research.

Specimen Requirements
  • Bone marrow aspirate: N/A
  • Peripheral blood: N/A
  • Fluids: N/A
  • Paraffin block: Send paraffin block. Also send circled H&E slide for tech-only (required).
  • Cut slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88377x1 manual or 88374x1 automated.
New York Approved
Level of Service
Turnaround Time

3-5 days

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.