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MAL is a distinct molecular marker of primary mediastinal large B-cell lymphoma subtype among diffuse large B-cell lymphomas.
Immunohistochemistry (IHC)
Probes: MALT1 (18q21) Disease(s): Marginal zone B-cell lymphoma, NHL
FISH
Mammaglobin is a breast-associated glycoprotein. In normal breast tissue, this antibody labels breast ductal and lobular epithelial cells. In tumor cells, they are reactive with all types of breast adenocarcinoma regardless of tumor differentiation…
Immunohistochemistry (IHC)
MAP2K1 mutation analysis is performed by next-generation sequencing of all coding exons of the MAP2K1 gene (formerly named MEK1).
Molecular
Special stain.
Immunohistochemistry (IHC)
Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing. Markers are CD2, CD25, CD34, CD45, and CD117 (5…
Flow Cytometry
Probes: MDM2 (12q15) | Centromere 12 Disease(s): Liposarcoma
FISH
Immunohistochemistry (IHC)
Probes: RPN1, MECOM (3q21, 3q26.2) | 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | ETV6 (12p13) | 17p- (TP53 17p13.1, NF1 17q11.2) | +19 (19p13.2, 19q13) | 20q- (20q12, 20qter) Probes may be ordered…
FISH
Probes: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (7q31, Cen 7) | Trisomy 8 (Cen 8) | MLL (11q23) | 20q- (20q12, 20qter) Probes may be ordered separately except +8 and 20q- which are combined. Disease(s): Myelodysplastic syndrome
FISH
Probes: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | 20q- (20q12, 20qter) Probes may be ordered separately except +8 and 20q- which are combined. Disease(s): Myelodysplastic syndrome
FISH
Melan A (Mart1, Melanoma Antigen Recognized by T-cells 1), is a differentiation antigen that is expressed in melanocytes, most melanomas. Melan A recognizes a subcellular fraction found in melanosomes. Melan A is a useful addition to melanoma panels…
Immunohistochemistry (IHC)
Mesothelin is a 40kDa cell surface glycoprotein selectively expressed by mesothelial cells and malignant mesotheliomas, as well as by non-mucinous ovarian carcinomas, breast carcinomas, pancreatic carcinomas, and squamous tumors of the esophagus and…
Immunohistochemistry (IHC)
MET Exon 14 Deletion Analysis is performed by real-time RT-PCR. The assay is designed to detect alternative splice junctions that lead to exon-skipping (deletion) of exon 14 of the gene MET. Note: Available as stand-alone test or as part of the…
Molecular
Probes: MET (7q31) | Centromere 7 Disease(s): Multiple solid tumor cancers including lung (NSCLC), gastric, esophageal, endometrial
FISH
Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the MGMT gene promoter. Percentage of methylated DNA (compared to total DNA) is reported for positive results.
Molecular
PCR and fragment analysis of paired normal and tumor tissue to determine microsatellite instability (MSI) at the standard five NCI-recommended loci. Positive results are reported as MSI-high (at least two markers are unstable) or MSI-low (one marker…
Molecular
MITF (microphthalmia transcription factor) is a transcription factor that regulates the development and survival of melanocytes. MITF is restricted to the melanocyte cell lineage. Anti-MITF recognizes a nuclear protein that is expressed in the…
Immunohistochemistry (IHC)
MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. During DNA replication, strand misalignment can occur resulting in alterations to microsatellite repeats, often referred to…
Immunohistochemistry (IHC)
This assay is performed on tumor tissue to detect hypermethylation of the MLH1 gene promoter. Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the promoter. Percentage of methylated DNA (compared to…
Molecular
Probes: MLL (11q23) Disease(s): ALL, AML
FISH
Detects the MLL partial tandem duplication (PTD) between exons 2 and 8 in the MLL gene by polymerase chain reaction (PCR).
Molecular
A well-defined subtype of colorectal cancer (CRC) is characterized by deficiencies in the mismatch repair (MMR) pathway. MMR status may impact prognosis and benefit of adjuvant chemotherapy. MLH1, MSH2, MSH6, and PMS2 protein expression (as assessed…
Immunohistochemistry (IHC)
Monoclonal antibody MOC31 recognizes a membrane glycoprotein of 40kDa present on epithelial cells but not on mesothelial cells. MOC31 reacts with most adenocarcinomas of various origins, typically with strong staining pattern. Only rare cases of…
Immunohistochemistry (IHC)
Bi-directional sequencing of exon 10 of the MPL gene to detect all possible mutations at the W515 and S505 codons, and other mutations throughout the exon. Testing is performed on plasma for increased sensitivity whenever possible. This test may be…
Molecular