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Probe(s): JAK2 (9p24.1)Disease(s): Eosinophilia, Myeloproliferative Neoplasms (MPN) Also available as part of ALL FISH Panel (Ph-Like)
FISH
RT-PCR and bi-directional sequencing to detect non-V617F mutations in exons 12-14 and most of exon 15, corresponding to the majority of the JAK2 pseudokinase domain. Exon deletion mutations are detectable. Testing is performed on plasma for…
Molecular
Qualitative detection of the V617F mutation. The rare mutation V617I is also detected. Testing is performed on plasma for increased sensitivity whenever possible. V617F testing may be ordered separately, concurrently with full exon 12-14 sequencing…
Molecular
Quantitative detection of the V617F mutation, which is commonly found in myeloproliferative neoplasms (MPN). DNA is isolated and subjected to allele-specific polymerase chain reaction (PCR) amplification. Test report includes a bar graph to trend…
Molecular