Methodology
FISH
Test Description

Probes: IgH/MAFB t(14;20)
This probe combination may be ordered separately or added to any of our mye
Disease(s): Myeloma, MGUSloma FISH panels.

Clinical Significance

The translocation (14;20) is rare in multiple myeloma (MM) but associated with a poor prognosis for that diagnosis. In contrast, t(14;20) in patients with MGUS is associated with a long-term stable disease.

Specimen Requirements
  • Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
  • Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
  • Fresh, Unfixed Tissue: Tissue in RPMI.
  • Fluids: Equal parts RPMI to specimen volume.
  • Paraffin Block or Cut Slides: Not available.
Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88374x1 automated. Codes may differ if manual analysis is performed.
Turnaround Time

3-5 days

Level of Service
Global
Technical

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.