Alternative Name
CD278
Methodology
Immunohistochemistry (IHC)
Test Description
ICOS (Inducible Co-Stimulator, CD278) is a member of the CD28 family that regulates T-cell activity and immune responses. ICOS is primarily expressed on activated CD4+ and CD8+ T-cells. It plays an important role in the diagnosis of T-cell lymphomas of follicular helper T-cell origin, and is useful when combined with multiple markers for follicular helper T-cells.
Specimen Requirements
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
or - One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage & Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88342x1 or 88341x1
Turnaround Time
24 hours
Level of Service
Stain Only
New York Approved
Yes
Notes
Global prognostic interpretation is available