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High-Grade/Large B-Cell Lymphoma Panel (NY and non-NY)
- FISH
Probes: BCL6 (3q27) | MYC (8q24) | BCL2 (18q21) | MYC/IgH/CEN8 t(8;14)
Optional Reflex: IGK/MYC t(2;8) | IGL/MYC t(8;22) | BCL6/MYC t(3;8), if MYC (8q24) is positive and MYC/IgH/CEN8 t(8;14) is negative
Disease(s): B-cell lymphoma, double-hit lymphoma, triple-hit lymphoma
Specimen Requirements
Bone marrow aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable. Peripheral blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable. Fresh, unfixed tissue: Tissue in RPMI. Bone Marrow/ Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: minimum *3-5 slides* labeled with specimen type. NOTE: 3 slides needed for base 3 probe panel, 1 slide needed if optional 14;18 added, 1 slide needed if optional 8;14 added Fluids: Equal parts RPMI to specimen volume Fixed Cell Suspension: A client fixed cell suspension may be submitted for testing as long as it is received in 3:1 Methanol:Glacial Acetic Acid. Paraffin block: H&E slide (required) plus paraffin block. Circle H&E for tech-only. Cut slides: H&E slide (required) plus 8 unstained slides cut at 4 microns. Circle H&E for tech-only. Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x4 automated. If reflex is added, add 88374x3. Codes may differ if manual analysis is performed.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: January 22, 2025