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High-Grade B-Cell Lymphoma Reflex FISH Panel
- FISH
Probes: MYC (8q24) | MYC/IgH/CEN8 t(8;14) Reflex Scheme: Reflex to BCL2 (18q21) and BCL6 (3q27) if MYC/IgH/CEN8 t(8;14) is positive OR Reflex to BCL2 (18q21), BCL6 (3q27), IGK/MYC t(2;8), IGL/MYC t(8;22), and BCL6/MYC t(3;8) if MYC (8q24) is positive and MYC/IgH/CEN8 t(8;14) is negative Disease(s): B-cell lymphoma, double-hit lymphoma, triple-hit lymphoma Note: This test is available on a global basis. Tech-only clients may order probes individually.
Turnaround time
3-5 Days
Level of Service
- Global
New York Approved: Yes
Specimen Requirements
Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable. Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable. Fresh, Unfixed Tissue: Tissue in RPMI. Bone Marrow/ Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: minimum *3 slides* labeled with specimen type. NOTE: Technically 1 TP is required since MYC would initially be ordered and other probes only reflexed if MYC was positive Fluids: Equal parts RPMI to specimen volume Fixed Cell Suspension: A client fixed cell suspension may be submitted for testing as long as it is received in 3:1 Methanol:Glacial Acetic Acid. Paraffin Block: Paraffin block acceptable. Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4 microns. Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Storage and Transportation
Storage & Transportation: Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x2 automated or 88377x2 manual without reflex; with reflex option 1, add 88374x2 automated or 88377x2 manual; with reflex option 2, add 88374x5 automated or 88377x5 manual
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: January 22, 2025