Methodology
Immunohistochemistry (IHC)
Test Description
Anti-Hepatocyte Specific Antigen (HepPar1) recognizes both benign and malignant liver derived tumors such as hepatoblastoma, hepatocellular carcinoma and hepatic adenoma. It recognizes both adult and fetal liver tissue. The typical pattern is a granular cytoplasmic staining. This antibody is useful in differentiating hepatocellular carcinomas from adenocarcinomas, either primary or metastatic. HepPar1 also can be used in differential diagnostic separation of hepatoblastoma versus other small round cell tumors. HepPar1 is also expressed in a subset of gastric carcinoma.
Specimen Requirements
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
or - One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage & Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88342 x 1 or 88341 x 1
Turnaround Time
24 hours
Level of Service
Stain Only
New York Approved
Yes