Methodology
Immunohistochemistry (IHC)
Test Description
Hepatitis B virus belongs to the hepatovirus family and causes type B hepatitis. Hepatitis B virus is spherical in shape with a diameter of 42 nm. Core antigens are localized within the nuclei, whereas the surface antigens are present in the cytoplasm of the infected cells. Antibodies to surface antigens appear in circulation at an early stage of infection, whereas the antibodies to the core antigens are detected in blood after several weeks. Hepatitis B core antibody targets Hepatitis B Virus Core Antigen in IHC applications.
Specimen Requirements
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
or - One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage & Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88342 x 1 or 88341 x 1
Turnaround Time
Global: 48 hours, Tech-Only (stain only): 24 hours
Level of Service
Global
Stain Only
New York Approved
Yes