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Methodology
Immunohistochemistry (IHC)
Test Description

H3K27me3 (trimethylation at lysine 27 of histone H3) is involved in the modification of DNA by protein Histone H3. Complete loss of H3K27me3 expression by immunohistochemistry can be useful in the diagnosis of malignant peripheral nerve sheath tumors (MPNST).

Clone: C36B11
Staining pattern: Nuclear

Specimen Requirements
  • A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
    or

  • One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered

  • Note: Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88342x1 or 88341x1
Turnaround Time

24 Hours

New York Approved
Yes
Level of Service
Stain Only

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.