Glycophorin A (sialoglycoprotein alpha) is one of two transmembrane proteins exposed on the outer surface of normal human erythrocytes. This monoclonal antibody reacts with an epitope located on the extracellular domain of glycophorin A and does not cross-react with glycophorin D (glycophorin delta). In normal human erythrocytes, glycophorin A is expressed during all stages of differentiation, from the normoblast to the mature erythrocyte. Once maximally expressed, the quantity of glycophorin A in each red blood cell remains constant. Glycophorin A has also been located in the blast cells of cases of erythroleukemia. Cases of acute lymphoblastic and myeloblastic leukemia are not reactive.
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
- One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.