Galectins are a structurally-related family of proteins; 14 different galectins have been characterized. They are cytoplasmic proteins and can be translocated into the nucleus. Gal-3 has been found overexpressed in most malignant thyroid neoplasms. However, it was not detectable in normal and non-malignant tissue. Galectin 3 is a useful marker to differentiate benign from malignant (Galectin 3-positive) thyroid neoplasms.
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
- One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.