FISH
1p36 Deletion Alternative Name Deletion 1p36 Methodology FISH Test Description Probes: TNFRSF14 (1p36) Disease(s): Follicular Lymphoma (FL)…
Molecular
B-Cell Gene Rearrangement Alternative Name B-Cell Translocations Methodology Molecular Test Description Detection of clonal IgH gene rearragements by PCR of IgH…
Immunohistochemistry (IHC)
BCL1/Cyclin D1 Methodology Immunohistochemistry (IHC) Test Description BCL1/Cyclin D1 is a nuclear protein detectable in formalin-fixed, paraffin-embedded (FFPE) sections and is found in the majority…
Immunohistochemistry (IHC)
BCL2 Methodology Immunohistochemistry (IHC) Test Description B-cell lymphoma 2 (BCL2) was the first of the translocation-associated proteins to be identified in lymphoma. Most cases of follicular…
FISH
BCL2 (18q21) Alternative Name B-cell lymphoma Methodology FISH Test Description Probes: BCL2 (18q21) Disease(s): B-cell lymphoma, non-Hodgkin lympoma (NHL), follicular…
Immunohistochemistry (IHC)
BCL6 Methodology Immunohistochemistry (IHC) Test Description BCL6 antibody stains the germinal center cells in lymphoid follicles, the follicular cells and interfollicular cells in follicular lymphoma…
FISH
BCL6 (3q27) Alternative Name B-cell lymphoma Methodology FISH Test Description Probes: BCL6 (3q27) Disease(s): Diffuse large B-cell lymphoma, NHL…
Immunohistochemistry (IHC)
CD10 Methodology Immunohistochemistry (IHC) Test Description CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA), is expressed in early lymphoid progenitors and normal germinal…
Immunohistochemistry (IHC)
CD19 Methodology Immunohistochemistry (IHC) Test Description CD19 recognizes a 95kD cell surface glycoprotein which is expressed by cells of the B-cell lineage and follicular dendritic cells. CD19 is…
Immunohistochemistry (IHC)
CD20 Methodology Immunohistochemistry (IHC) Test Description Normal cell expression of CD20 is found on most B-cells (after CD19 and CD10 expression, before CD21/22 expression and surface…
Immunohistochemistry (IHC)
CD21 Methodology Immunohistochemistry (IHC) Test Description CD21 (CR2, C3d receptor and EBV receptor) is expressed strongly on mature B-cells, follicular dendritic cells (FDC) and weakly on immature…
Immunohistochemistry (IHC)
CD22 Methodology Immunohistochemistry (IHC) Test Description CD22 expression is restricted to normal and neoplastic B-cells and is absent from other hemopoietic cell types. In B-cell ontogeny, CD22 is…
Immunohistochemistry (IHC)
CD3 Methodology Immunohistochemistry (IHC) Test Description The CD3 antigen is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to…
Immunohistochemistry (IHC)
CD35 Methodology Immunohistochemistry (IHC) Test Description CD35 antigen is a transmembrane protein of 160-250 kDa that binds complement components C3b and C4b. It mediates phagocytosis by…
Immunohistochemistry (IHC)
CD79a Methodology Immunohistochemistry (IHC) Test Description CD79a first appears at the pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component.…
Cytogenetics, FISH, Flow Cytometry, Immunohistochemistry (IHC), Molecular
COMPASS® Hematopathology Services Alternative Name COMPASS® Bone Marrow Evaluation, COMPASS® Peripheral Blood Evaluation Methodology Cytogenetics FISH Flow Cytometry…
Cytogenetics, FISH, Flow Cytometry, Immunohistochemistry (IHC), Molecular
COMPASS® Select Hematopathology Services Alternative Name COMPASS® Select Bone Marrow Evaluation, COMPASS® Select Peripheral Blood Evaluation Methodology Cytogenetics FISH Flow Cytometry…
Immunohistochemistry (IHC)
FOXP1 Methodology Immunohistochemistry (IHC) Test Description FOX P1 (Forkheadbox-P1) is a transcription factor widely expressed in normal tissues. Its expression is commonly deregulated in…
Immunohistochemistry (IHC)
HGAL Methodology Immunohistochemistry (IHC) Test Description HGAL is specifically expressed in the cytoplasm of germinal center B-cells, but is absent in mantle and marginal zone. This antibody is…
FISH
High-Grade B-Cell Lymphoma Reflex FISH Panel Methodology FISH Test Description Probes: MYC (8q24) | MYC/IgH/CEN8 t(8;14) Reflex Scheme: Reflex to BCL2 (18q21) and BCL6 (3q27) if MYC/IgH/CEN8 t(8;14)…
FISH
High-Grade/Large B-Cell Lymphoma Panel (NY and non-NY) Alternative Name Large B-Cell Lymphoma Methodology FISH Test Description Probes: BCL6 (3q27) | MYC (8q24) | BCL2…
FISH
IgH (14q32) Alternative Name Immunoglobulin heavy chain Methodology FISH Test Description Probes: IgH (14q32) Disease(s): Lymphoma, NHL, multiple myeloma, MGUS…
Molecular
IgH Clonality by NGS Methodology Molecular Test Description The IgH Clonality by NGS assay detects clonal populations of B-lymphocytes in a given patient sample through the analysis of the VDJ segment…
Immunohistochemistry (IHC)
Ki-67 Methodology Immunohistochemistry (IHC) Test Description Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases…
Immunohistochemistry (IHC)
LEF1 Methodology Immunohistochemistry (IHC) Test Description LEF1 overexpression is highly associated with CLL/SLL among small B-cell lymphomas and may serve as a useful marker for diagnosis and…