Available as a global test only. DNA stain propidium iodide (PI) is used to determine S-phase cell cycle fraction and DNA index as indicators of DNA ploidy. Products of conception (POC) and solid tumors are accepted for this test. Please see DNA Ploidy/Cell Cycle Analysis – Heme for other indications.
DNA ploidy analysis in POC can detect diploid, triploid, and tetraploid cell populations to help distinguish hydatidiform molar, partial mole, and non-molar pregnancies. In cancer, S-phase and ploidy analysis have diagnostic and prognostic value in assessment of some tumors. In general, high S-phase fractions and/or aneuploidy may be associated with a more aggressive tumor.
- FFPE samples: Please submit block. POC samples should contain villi or fetal tissue. Testing is not available on fresh (unfixed) tissue.
Specimens should be received at NeoGenomics within 72 hours from collection to assure sample integrity and acceptable cell viability. Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.