Methodology
Flow Cytometry
Test Description

Available as a global test only. DNA stain propidium iodide (PI) is used to determine S-phase cell cycle fraction and DNA index as indicators of DNA ploidy. Products of conception (POC) and solid tumors are accepted for this test. Please see DNA Ploidy/Cell Cycle Analysis – Heme for other indications.

Clinical Significance

DNA ploidy analysis in POC can detect diploid, triploid, and tetraploid cell populations to help distinguish hydatidiform molar, partial mole, and non-molar pregnancies. In cancer, S-phase and ploidy analysis have diagnostic and prognostic value in assessment of some tumors. In general, high S-phase fractions and/or aneuploidy may be associated with a more aggressive tumor.

Specimen Requirements
  • FFPE samples: Please submit block. POC samples should contain villi or fetal tissue. Testing is not available on fresh (unfixed) tissue.
Storage and Transportation

Specimens should be received at NeoGenomics within 72 hours from collection to assure sample integrity and acceptable cell viability. Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88182
Turnaround Time

4 days

Level of Service
Global

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.