Probes: DDIT3 (CHOP) (12q13)
Disease(s): Myxoid-round cell liposarcoma (M/RCLS)
The DDIT3 break-apart FISH test detects 12q13 rearrangements in myxoid-round cell liposarcoma (M/RCLS). The DDIT3 locus was formerly named CHOP. Fusion of DDIT3 and FUS genes in t(12;16)(q13;p11) is detected in >95% of cases. Occasionally observed is t(12;22)(q13;q12) in which DDIT3 and EWSR1 are fused. DDIT3 rearrangement partners will not be identified by this FISH test. For that purpose, please see the NGS Sarcoma Fusion Profile
Storage and Transportation
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.