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D2 40 identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Anti-D2 40 has also been demonstrated to label lymphatic endothelium whereas it is unreactive with…

This antibody reacts with a subset of B-cells in the mantle zone and some immunoblasts outside the follicle. It reacts with most hairy cell leukemia cases. This antibody shows strong positive staining in some high grade B-cell lymphoma cases.

Probes: DDIT3 (CHOP) (12q13) Disease(s): Myxoid-round cell liposarcoma (M/RCLS)

Desmin is an intermediate filament protein of both smooth and striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well as smooth muscle cells. Anti-desmin antibody is useful in identification of tumors of myogenic…

Delta-like protein 3 (DLL3) expression is regulated by ASCL1, a transcription factor that is required for proper development of pulmonary neuroendocrine cells. IHC staining is useful in the diagnosis of lung small cell carcinoma (SCLC) and large…

STR (short tandem repeat) analysis by PCR and capillary electrophoresis (fragment analysis) is used to define sample identity and to identify mixtures of two or more genotypes within a single sample. Fifteen autosomal markers and one gender-based…

DNMT3A mutation analysis is performed by next-generation sequencing of all coding exons of the DNMT3A gene.

DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with Kit mutations the DOG1 antibody identified 11% more cases than c-Kit antibody. DOG1 identifies the vast…

The gene DPC4 (deleted in pancreatic carcinoma 4, also called SMAD4) was identified in 18q21.3 This gene is frequently mutated and deleted in pancreatic carcinomas (55%) and less frequently (20 - 22%) in colon carcinomas. Loss of expression is…

Probes: DUSP22-IRF4 gene region at 6p25.3 Disease(s): Anaplastic Large Cell Lymphoma (ALCL), large B-cell lymphoma