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D2 40 identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Anti-D2 40 has also been demonstrated to label lymphatic endothelium whereas it is unreactive with…
Immunohistochemistry (IHC)
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This antibody reacts with a subset of B-cells in the mantle zone and some immunoblasts outside the follicle. It reacts with most hairy cell leukemia cases. This antibody shows strong positive staining in some high grade B-cell lymphoma cases.
Immunohistochemistry (IHC)
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Probes: DDIT3 (CHOP) (12q13)
Disease(s): Myxoid-round cell liposarcoma (M/RCLS)
FISH
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Desmin is an intermediate filament protein of both smooth and striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well as smooth muscle cells. Anti-desmin antibody is useful in identification of tumors of myogenic…
Immunohistochemistry (IHC)
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Delta-like protein 3 (DLL3) expression is regulated by ASCL1, a transcription factor that is required for proper development of pulmonary neuroendocrine cells. IHC staining is useful in the diagnosis of lung small cell carcinoma (SCLC) and large…
Immunohistochemistry (IHC)
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STR (short tandem repeat) analysis by PCR and capillary electrophoresis (fragment analysis) is used to define sample identity and to identify mixtures of two or more genotypes within a single sample. Fifteen autosomal markers and one gender-based…
Molecular
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DNMT3A mutation analysis is performed by next-generation sequencing of all coding exons of the DNMT3A gene.
Molecular
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DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with Kit mutations the DOG1 antibody identified 11% more cases than c-Kit antibody. DOG1 identifies the vast…
Immunohistochemistry (IHC)
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The gene DPC4 (deleted in pancreatic carcinoma 4, also called SMAD4) was identified in 18q21.3 This gene is frequently mutated and deleted in pancreatic carcinomas (55%) and less frequently (20 - 22%) in colon carcinomas. Loss of expression is…
Immunohistochemistry (IHC)
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Probes: DUSP22-IRF4 gene region at 6p25.3
Disease(s): Anaplastic Large Cell Lymphoma (ALCL), large B-cell lymphoma
FISH
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