Bi-directional sequencing of exons 14 and 17 of the CSF3R gene which includes detection of the common mutation T618I (also known as T595I).
CSF3R mutations are newly-identified genetic markers detected in 59% of chronic neutrophilic leukemia (CNL) or atypical chronic myeloid leukemia (aCML) that are useful for diagnosis and classification of these disorders. Identification of specific mutations may suggest the class of kinase inhibitors to which the tumor will be sensitive. Mutations are also detected in 30-80% of leukemia in patients with severe congenital neutropenia (SCN).
- Peripheral blood: 5 mL in EDTA tube.
- Bone marrow: 2 mL in EDTA tube.
Note: Test is DNA-based. Please select Extract & Hold - DNA if specimen hold service is desired.
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
10 days