Alternative Name
Chronic lymphocytic leukemia
Methodology
FISH
Test Description
Probes: 6q- [SEC63 (6q21), MYB (6q23)] | ATM (11q22.3) | p53 (17p13.1) | Trisomy 12 (Cen 12) | 13q-/-13 (13q14, 13q34) | CCND1/IgH t(11;14) | Probes may be ordered separately (except 12 and 13 are tested together, and ATM is tested with p53).
Disease(s): Chronic lymphocytic leukemia
Note: This test was previously called CLL FISH Panel (non-New York). It is now New York state-approved and available to all clients.
Disease(s): Chronic lymphocytic leukemia
Note: This test was previously called CLL FISH Panel (non-New York). It is now New York state-approved and available to all clients.
Clinical Significance
The CLL FISH panel is used for the detection of chromosome aberrations observed in chronic lymphocytic leukemia/small lymphocytic lymphoma, which are useful in prognosis and prediction of time to treatment in CLL patients when used in combination with other clinical and diagnostic findings. CCND1/IgH is used to rule out mantle cell leukemia/lymphoma.
Specimen Requirements
- Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
- Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
- Fresh, Unfixed Tissue: Tissue in RPMI.
- Fluids: Equal parts RPMI to specimen volume
- Paraffin Block or Cut Slides: Not available.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88374x4 automated. Codes may differ if manual analysis is performed.
Turnaround Time
3-5 days
New York Approved
Yes
Level of Service
Global
Technical