Test by Disease - Central nervous system (CNS)

53 Tests in Listing


1p/19q Deletions for Glioma

Probes: 1p36/1q25 |19q13/19p13
Disease(s): Oligodendroglioma
Ratios of p:q signals are determined for eac...

FISH

ACTH

Anti-adrenocorticotropic hormone (ACTH) is a useful marker in the classification of pituitary tumors and the study of pituitary disease. It reacts wit...

IHC

ATRX

ATRX mutations predominantly occur in grade II/III astrocytoma and secondary glioblastoma multiforme (GBM) brain tumors. ATRX loss defines a subgro...

IHC

ATRX Mutation Analysis

Bi-directional Sanger sequencing of ATRX is performed using PCR primers designed to target hotspot mutations in exons 8-10, 12-15, 17, 18, 21, 22, 26,...

Molecular

BRAF Mutation Analysis

Bi-directional sequencing of exon 15 of the BRAF gene, which includes qualitative detection of V600 mutations E, K, D, and others, plus other signific...

Molecular

BRAF Rearrangement

Probes: BRAF (7q34)
Disease(s): Brain cancer, thyroid cancer, melanoma

FISH

CD31

CD31 is a 130kDa transmembrane glycoprotein that is shared by vascular lining cells, megakaryocytes and platelets. This marker is highly restricted to...

IHC

cMET

The cMET tyrosine kinase receptor, normally expressed by epithelial cells, is overexpressed and amplified in a variety of human tumors, including non-...

IHC

CMV

In situ hybridization for detection of cytomegalovirus (CMV) RNA.

ISH

COX2

Cyclooxygenase-2 (COX-2) plays a role in tumorigenesis through stimulating epithelial cell proliferation, inhibiting apoptosis, stimulating angiogenes...

IHC

EGFR Amplification

Probes: EGFR (7p11.2) | Centromere 7
Disease(s): Brain, lung, colorectal, gastric, breast cancers

FISH

EGFR Mutation Analysis

Bi-directional sequencing of exons 18-21 of the EGFR gene for detection of EGFR-activating mutations and TKI resistance mutations (including T790M) in...

Molecular

EGFRvIII Analysis

The EGFRvIII Analysis test is a real-time quantitative RT-PCR assay that is capable of detecting the EGFRvIII mutation that results from an inframe de...

Molecular

FSH

Follicle Stimulating Hormone (FSH) is a pituitary hormone involved in the maturation of ovarian follicles and estrogen secretion in females. In the p...

IHC

GFAP

Glial Fibrillary Acidic Protein (GFAP) is the major protein found in astrocytes and its expression is evidence of astroglial origin and differentiatio...

IHC

GH

Growth Hormone (GH) is produced by the somatotroph cells in the pituitary. This marker is a useful in classification of pituitary tumors and the st...

IHC

Hereditary Cancer Susceptibility for Pediatrics

The Hereditary Cancer Susceptibility for Pediatrics panel is a sequencing based assay that can detect mutations in the entire coding region of the following genes listed. ALK, APC, BRCA1, BRCA2, CDH1, KRAS, MSH2, MSH6, NF1, NF2, NRAS, PALB2, PMS2, PTCH1, RB1, RET, RUNX1, SDHA, SDHB, TP53, and VHL. Note: Parent and physician or genetic counselor signatures on the NeoGenomics Consent for Hereditary Cancer Genetic Testing form...

Molecular

HPL

Human Placental Lactogen (HPL) is a polypeptide hormone synthesized in syncytiotrophoblastic cells of placenta and has been used as a tissue marker fo...

IHC

HSV I

This antibody reacts with Herpes Simplex Virus (HSV) type 1 specific antigens and with antigens common for HSV types 1 and 2. The antibody reacts with...

IHC

HSV II

This antibody reacts with Herpes Simplex Virus (HSV) type 2 specific antigens and with antigens common for HSV types 1 and 2. The antibody reacts with...

IHC

IDH1

IDH1 mutations are frequent genetic alterations in low-grade diffuse gliomas and secondary glioblastoma (70%). This alteration is observed in fewer...

IHC

IDH1 & IDH2 Mutation Analysis

Bi-directional sequencing of the exon 4 mutation hotspot regions in both the IDH1 and IHD2 genes. IDH1 and IDH2 are analyzed concurrently. In hemat...

Molecular

Ki67

Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cell ...

IHC

LH

Luteinizing Hormone (LH) is a tropic hormone that modulates the secretory activity of other endocrine glands. It is produced in the anterior hypophys...

IHC

MET FISH

Probes: MET (7q31) | Centromere 7
Disease(s): Multiple solid tumor cancers including lung (NSCLC), gastric, es...

FISH

MGMT Promoter Methylation Analysis

Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the MGMT gene promoter. Percentage of methylated DNA...

Molecular

NeoARRAY™ SNP/Cytogenetic Profile

The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage a...

Molecular

NeoARRAY™ SNP/Cytogenetic Profile

The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage a...

Cytogenetics

NeoLAB™ Solid Tumor Monitor - Liquid Biopsy

The NeoLAB™ Solid Tumor Monitor is a blood test that uses cell-free circulating tumor DNA (ctDNA) or RNA in combination with next-generation ...

Molecular

NeoTYPE Brain Tumor Profile

This test is performed by the sequencing of select exons of the genes listed unless another method is noted. AKT1, ATRX, BRAF, CDK6, CDKN2A, CIC, CTNNB1, EGFR, EGFRvIII Analysis, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, FUBP1, H3F3A, HRAS, IDH1, IDH2, KRAS, MET, MGMT Promoter Methylation Analysis, MYC, MYCN, NF1, NF2, NRAS, PIK3CA, PTCH1, PTEN, RB1, SETD2, SMAD4, SMO, SRC, TERT Promoter, TP53, 1p/19q Deletion FISH, BRAF FISH, MET FISH, MYCN FISH, PDGFRA FISH, PTEN FISH, and PD-L1 IHC. Individual genes from a validated list of solid tumor genes can be added-on. Tumor Mutation Burden (TMB) testing and individual genes from a validated list of solid tumor genes can be added. Test orders include summary interpretation of all results together. FISH components of NeoTYPE Profiles may be ordered as “Tech-Only” by pathology clients who wish to perform the professional component.
For more information, please visit our NeoTYPE Brain Tumor Profile page...

Molecular

NeoTYPE Cancer Exome Profile

The NeoTYPE™ Cancer Exome Profile is performed by massive parallel sequencing of the coding regions in 4813 different cancer related genes. T...

Molecular

NeoTYPE Discovery Profile for Solid Tumors

This test is performed by the sequencing of select exons of the genes listed unless another method is noted. ABL1, ABL2, ACVR1B, AKT1, AKT2, AKT3, ...

Molecular

NeoTYPE Other Solid Tumor Profile

This test is performed by the sequencing of select exons of the genes listed unless another method is noted. AKT1, BRAF, EGFR, FGFR1, FGFR2, FGFR3,...

Molecular

NeoTYPE Precision Profile for Solid Tumors

The NeoTYPE Precision Profile for Solid Tumors utilizes next-generation sequencing to detect mutations in the following 48 genes: ABL1, AKT1, ALK, ...

Molecular

NeuN

NeuN is a sensitive and specific marker of neuronal differentiation in brain tumors.

IHC

NSE (Neuron Specific Enolase)

In normal tissue, most neurons and their axonal and dendritic processes stain strongly positive for Neuron Specific Enolase (NSE), with the exception ...

IHC

Olig2

Olig2, a transcription factor, is involved in oligodendroglial specification. Olig2 expression has been reported in most glial tumors, such as oligode...

IHC

p21

p21 is a cyclin dependent protein kinase inhibitor and is a member of a family of proteins that functions to slow down cell division. p21 is found in ...

IHC

p53

The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results ...

IHC

PDGFRA Amplification

Probes: PDGFRA (4q12) | Centromere 4
Disease(s): Brain cancer

FISH

pHistone H3 (PHH3)

Phosphohistone H3 (PHH3) is a marker of cells in the late G2-M phase of the cell cycle. It is not expressed in apoptotic cells which may be confused w...

IHC

PIK3CA Mutation Analysis

Bi-directional sequencing of PIK3CA exons 1, 9, and 20 which are the most commonly-mutated regions of the gene.

Molecular

Prolactin

Prolactin is a growth factor secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Pro...

IHC

PTEN Mutation Analysis

Bi-directional sequencing of all exons (1-9) of the PTEN gene. For solid tumors, enrichment is performed befor...

Molecular

SOX2

SOX2 stains all embryonal carcinomas and is highly specific for squamous cell carcinoma.

IHC

Tau

Tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles (NFTs) characteristic of ...

IHC

TERT Promoter Mutation Analysis

Bi-directional Sanger sequencing is performed using PCR primers designed to target mutations in the promoter region of TERT.

Molecular

TP53 Mutation Analysis

Bi-directional sequencing of TP53 exons 4-9.

Molecular

TSH

Thyroid Stimulating Hormone (TSH) is a pituitary hormone of 28 kDa that stimulates thyroid growth and production of thyroid hormones. This antibody la...

IHC

Tumor Mutation Burden

Tumor Mutation Burden (TMB) testing at NeoGenomics measures the number of non-synonymous DNA coding sequence changes per megabase of sequenced DNA....

Molecular

UGT1A1 Genotyping

Lengths of the TA repeat polymorphism in the promoter region of the UTG1A1 gene are determined by fragment analysis using capillary electrophoresis. T...

Molecular

Universal Fusion/Expression Profile

The Universal Fusion/Expression Profile is a targeted RNA sequencing panel that utilizes next-generation sequencing (NGS) to detect all relevant fusion transcripts in 1,385 genes associated with hematologic or solid tumor cancers. It is especially useful for testing patients with rare diseases. Learn more about the Universal Fusion/Expression Profile...

Molecular

Vimentin

Vimentin is the major intermediate filament in a variety of mesenchymal cells, including endothelial cells, all fibroblastic cells, macrophages, Serto...

IHC

 

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