Methodology
Immunohistochemistry (IHC)
Test Description
CD35 antigen is a transmembrane protein of 160-250 kDa that binds complement components C3b and C4b. It mediates phagocytosis by neutrophils and monocytes. CD35 is found on erythrocytes, B-cells, a subset of T-cells, monocytes, macrophages cultured in vitro, neutrophils, eosinophils, glomerular podocytes and follicular dendritic cells. CD35 antibody is useful in the diagnosis of mucosa-associated lymphoid tissue (MALT) lymphoma and in the study of inflammatory disorders. It also labels follicular dendritic cell sarcoma.
Specimen Requirements
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
or - One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage & Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88342 x 1 or 88341 x 1
Turnaround Time
24 hours
Level of Service
Stain Only
New York Approved
Yes