CD23 is identical to low affinity IgE receptor found on B-cells. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B-lymphoblastoid cell lines. CD23 is most useful in distinguishing B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) from other entities and may remain present in CLL/SLL that has undergone large cell transformation.
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
- One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.