Methodology
Immunohistochemistry (IHC)
Test Description
Calretinin is the most specific and reproducible positive marker of epithelial mesothelioma. Calretinin is a calcium-binding protein similar to S100 protein. It is found in the central and peripheral nervous system and in a wide spectrum of non-neural cells, including steroid-producing cells of ovaries and testes, fat cells, renal tubular epithelial cells, eccrine glands, thymic epithelial cells and mesothelial cells. Calretinin immunostaining is found in most epithelial mesotheliomas.
Specimen Requirements
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
or - One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage & Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88342x1or 88341x1
Turnaround Time
24 hours
Level of Service
Stain Only
New York Approved
Yes