Beta-catenin is an important regulator of cell–cell adhesion and embryogenesis. Mutations of beta-catenin could lead to some human cancers. Normal cells show membrane staining for beta-catenin, while cytoplasmic and/or nuclear staining is abnormal. Dysregulation of beta-catenin occurs in Gardner syndrome, where it leads to both familial adenomatous polyposis and fibromatosis. Nuclear location of beta-catenin also occurs in colon and endometrioid ovarian carcinomas as well as in synovial sarcoma, osteosarcoma, liposarcoma, palisaded myofibroblastoma, and other sarcomas.
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
- One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.