Methodology
Immunohistochemistry (IHC)
Test Description
BCL2 is a protein associated with apoptosis regulation produced by the BCL2 gene and is comprised of an alpha and beta chain. BCL2 (clone SP66) shows negative reaction on reactive germinal centers and positive staining of neoplastic follicles in follicular lymphoma. This is useful in distinguishing between reactive and neoplastic follicular proliferation in lymphoid lesions. This is a sensitive antibody that may stain a greater proportion of follicular lymphomas than other BCL2 antibodies. See also BCL2 IHC.
Specimen Requirements
- A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type
or - One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
CPT Code(s)*
88342 x 1 or 88341 x 1
Turnaround Time
24 hours
Level of Service
Stain Only